...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Brachial Plexus and Peripheral Nerve Injury >Vascular mechanism of axonal degeneration in peripheral nerves in hemiplegic sides after cerebral hemorrhage: An experimental study
【24h】

Vascular mechanism of axonal degeneration in peripheral nerves in hemiplegic sides after cerebral hemorrhage: An experimental study

机译：脑出血后偏瘫侧周围神经轴突变性的血管机制：实验研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BackgroundThough retrograde neuronal death and vascular insufficiency have been well established in plegics following intracerebral hemorrhage, the effects of plegia on arterial nervorums of peripheral nerves have not been reported. In this study, the histopathological effects of the intracerebral hemorrhage on the dorsal root ganglions and sciatic nerves via affecting the arterial nervorums were investigated.MethodsThis study was conducted on 13 male hybrid rabbits. Three animals were taken as control group and did not undergo surgery. The remaining 10 subjects were anesthetized and were injected with 0.50 ml of autologous blood into their right sensory-motor region. All rabbits were followed-up for two months and then sacrificed. Endothelial cell numbers and volume values were estimated a three dimensionally created standardized arterial nervorums model of lumbar 3. Neuron numbers of dorsal root ganglions, and axon numbers in the lumbar 3 nerve root and volume values of arterial nervorums were examined histopathologically. The results were analyzed by using a Mann-Whitney-U test.ResultsLeft hemiplegia developed in 8 animals. On the hemiplegic side, degenerative vascular changes and volume reduction in the arterial nervorums of the sciatic nerves, neuronal injury in the dorsal root ganglions, and axonal injury in the lumbar 3 were detected. Statistical analyses showed a significant correlation between the normal or nonplegic sides and plegic sides in terms of the neurodegeneration in the dorsal root ganglions (p < 0.005), axonal degeneration in the lumbar 3 nerve roots (p < 0.005), endothelial cell degeneration in the arterial nervorums (p < 0.001), and volume reduction in the arterial nervorums (p < 0.001).ConclusionIntracerebral hemorrhage resulted in neurodegeneration in the dorsal root ganglion and axonolysis in the sciatic nerves, endothelial injury, and volume reduction of the arterial nervorums in the sciatic nerves. The interruption of the neural network connection in the walls of the arterial nervorums in the sciatic nerves may be responsible for circulation disorders of the arterial nervorums, and arterial nervorums degeneration could result in sciatic nerves injury.
机译：背景技术尽管在脑出血后的plegics中已经确定逆行性神经元死亡和血管功能不全，但尚未报道plegia对周围神经动脉神经的影响。本研究通过对13只雄性杂种兔进行研究，研究了脑出血对背根神经节和坐骨神经的组织病理学影响。方法将三只动物作为对照组，不进行手术。其余10名受试者被麻醉，并向其右感觉运动区注射0.50 ml自体血。对所有兔子进行随访两个月，然后处死。评估了三维创建的腰3标准化动脉神经模型的内皮细胞数目和体积值。对组织学检查了腰根神经节的神经元数目和腰3神经根的轴突数目和动脉神经的体积值。结果采用Mann-Whitney-U检验进行了分析。结果有8只动物出现了左偏瘫。在偏瘫方面，检测到了坐骨神经的血管变性退行性改变和体积减少，背根神经节的神经元损伤和腰椎3的轴突损伤。统计学分析显示，正常或非瘫痪侧与患侧之间在背根神经节的神经退行性变（p <0.005），腰3神经根的轴突退行性变（p <0.005），内皮细胞的退行性显着相关。结论：脑内出血导致背根神经节神经变性，坐骨神经轴突分解，内皮损伤以及动脉神经节体积减少。坐骨神经。坐骨神经中的动脉神经壁的神经网络连接的中断可能是导致动脉神经循环障碍的原因，并且动脉神经变性可能导致坐骨神经损伤。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号