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首页> 外文期刊>Journal of Brachial Plexus and Peripheral Nerve Injury >Intraperitoneal Alpha-Lipoic Acid to prevent neural damage after crush injury to the rat sciatic nerve
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Intraperitoneal Alpha-Lipoic Acid to prevent neural damage after crush injury to the rat sciatic nerve

机译：腹膜内α-硫辛酸可预防大鼠坐骨神经挤压伤后的神经损伤

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ObjectiveCrush injury to the sciatic nerve causes oxidative stress. Alfa Lipoic acid (a-LA) is a neuroprotective metabolic antioxidant. This study was designed to investigate the antioxidant effects of pretreatment with a-LA on the crush injury of rat sciatic nerve.MethodsForty rats were randomized into four groups. Group I and Group II received saline (2 ml, intraperitoneally) and a-LA (100 mg/kg, 2 ml, intraperitoneally) in the groups III and IV at the 24 and 1 hour prior to the crush injury. In groups II, III and IV, the left sciatic nerve was exposed and compressed for 60 seconds with a jeweler's forceps. In Group I (n = 10), the sciatic nerve was explored but not crushed. In all groups of rats, superoxide dismutase (SOD) and catalase (CAT) activities, as well as malondialdehyde (MDA) levels were measured in samples of sciatic nerve tissue.ResultsCompared to Group I, Group II had significantly decreased tissue SOD and CAT activities and elevated MDA levels indicating crush injury (p 0.05).ConclusionA-LA administered before crush injury of the sciatic nerve showed significant protective effects against crush injury by decreasing the oxidative stress. A-LA should be considered in the treatment of peripheral nerve injuries, but further studies are needed to explain the mechanism of its neuroprotective effects.
机译：目的挤压伤坐骨神经会引起氧化应激。阿尔法硫辛酸（a-LA）是一种神经保护性代谢抗氧化剂。本研究旨在探讨a-LA预处理对大鼠坐骨神经挤压伤的抗氧化作用。方法将40只大鼠随机分为四组。 I组和II组在挤压伤发生前24小时和1小时，分别在III组和IV组中接受盐水（2 ml，腹膜内）和a-LA（100 mg / kg，2 ml，腹膜内）。在第二，第三和第四组中，暴露左坐骨神经并用珠宝商的镊子压迫60秒。在第一组（n = 10）中，坐骨神经被探查但未被压碎。在所有组的大鼠中，测量坐骨神经组织样品中的超氧化物歧化酶（SOD）和过氧化氢酶（CAT）活性以及丙二醛（MDA）水平。结果与第一组相比，第二组的组织SOD和CAT活性显着降低。结论坐骨神经压伤前给予A-LA通过降低氧化应激对压伤具有明显的保护作用。在周围神经损伤的治疗中应考虑使用A-LA，但需要进一步的研究来解释其神经保护作用的机制。

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