...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Brachial Plexus and Peripheral Nerve Injury >Excitability changes in the sciatic nerve and triceps surae muscle after spinal cord injury in mice
【24h】

Excitability changes in the sciatic nerve and triceps surae muscle after spinal cord injury in mice

机译：小鼠脊髓损伤后坐骨神经和腓肠三头肌的兴奋性变化

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BackgroundFrom the onset to the chronic phase of spinal cord injury (SCI), peripheral axons and muscles are subjected to abnormal states of activity. This starts with very intense spasms during the first instant of SCI, through a no activity flaccidity phase, to a chronic hyperactivity phase. It remains unclear how the nature of this sequence may affect the peripheral axons and muscles.MethodsWe set out to investigate the changes in excitability of the sciatic nerve and to characterize the properties of muscle contractility after contusive injury of the mouse thoracic spinal cord.ResultsThe following changes were observed in animals after SCI: 1) The sciatic nerve compound action potential was of higher amplitudes and lower threshold, with the longer strength-duration time constant and faster conduction velocity; 2) The latency of the onset of muscle contraction of the triceps surae muscle was significantly shorter in animals with SCI; 3) The muscle twitches expressed slower rising and falling slopes, which were accompanied by prolonged contraction duration in SCI animals compared to controls.ConclusionThese findings suggest that in peripheral nerves SCI promotes hyperexcitability, which might contribute to mechanisms of spastic syndrome.
机译：背景从脊髓损伤（SCI）的发作到慢性期，周围的轴突和肌肉处于异常活动状态。这始于在SCI的第一个瞬间发生非常剧烈的痉挛，直至无活动松弛阶段，直至慢性活动过度阶段。目前尚不清楚该序列的性质如何影响周围的轴突和肌肉。方法我们着手研究坐骨神经兴奋性的变化，并表征小鼠胸脊髓挫伤性损伤后肌肉的收缩特性。 SCI后动物观察到变化：1）坐骨神经复合动作电位幅度较大，阈值较低，强度持续时间常数较长，传导速度较快。 2）在患有SCI的动物中，腓肠肌肱三头肌开始肌肉收缩的潜伏期明显缩短; 3）肌肉抽搐表现出较慢的上升和下降斜率，与对照组相比，伴有SCI动物的收缩持续时间延长。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号