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首页> 外文期刊>Journal of Cachexia, Sarcopenia and Muscle >Muscle mass and association to quality of life in non-small cell lung cancer patients
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Muscle mass and association to quality of life in non-small cell lung cancer patients

机译：非小细胞肺癌患者的肌肉质量及其与生活质量的关系

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Abstract Background Cancer wasting is characterized by muscle loss and may contribute to fatigue and poor quality of life (QoL). Our aim was to investigate associations between skeletal muscle index (SMI) and skeletal muscle radiodensity (SMD) and selected QoL outcomes in advanced non-small cell lung cancer (NSCLC) at diagnosis. Methods Baseline data from patients with stage IIIB/IV NSCLC and performance status 0?￠????2 enrolled in three randomized trials of first-line chemotherapy ( n = 1305) were analysed. Associations between SMI (cm 2 /m 2 ) and SMD (Hounsfield units) based on computed tomography-images at the third lumbar level and self-reported physical function (PF), role function (RF), global QoL, fatigue, and dyspnoea were investigated by linear regression using flexible non-linear modelling. Results Complete data were available for 734 patients, mean age 65 years. Mean SMI was 47.7 cm 2 /m 2 in men ( n = 420) and 39.6 cm 2 /m 2 in women ( n = 314). Low SMI values were non-linearly associated with low PF and RF (men P = 0.016/0.020, women P = 0.004/0.012) and with low global QoL ( P = 0.001) in men. Low SMI was significantly associated with high fatigue ( P = 0.002) and more pain ( P = 0.015), in both genders, but not with dyspnoea. All regression analyses showed poorer physical outcomes below an SMI breakpoint of about 42?￠????45 cm 2 /m 2 for men and 37?￠????40 cm 2 /m 2 for women. In both genders, poor PF and more dyspnoea were significantly associated with low SMD. Conclusions Low muscle mass in NSCLC negatively affects the patients' PF, RF, and global QoL, possibly more so in men than in women. However, muscle mass must be below a threshold value before this effect can be detected.
机译：摘要背景癌症消瘦的特征是肌肉丢失，可能导致疲劳和不良生活质量（QoL）。我们的目的是研究诊断时晚期非小细胞肺癌（NSCLC）的骨骼肌指数（SMI）和骨骼肌放射密度（SMD）与选择的QoL结果之间的关联。方法分析来自三项一线化疗的随机试验（n = 1305）的IIIB / IV期NSCLC患者的基线数据，其工作状态为0≤±2。 SMI（cm 2 / m 2）和SMD（Hounsfield单位）之间的关联基于第三级腰椎的CT图像和自我报告的身体功能（PF），角色功能（RF），总体QoL，疲劳和呼吸困难通过使用灵活非线性建模的线性回归研究。结果734例患者的完整数据可用，平均年龄65岁。男性的平均SMI为47.7 cm 2 / m 2（n = 420），女性的平均SMI为39.6 cm 2 / m 2（n = 314）。低SMI值与低PF和RF（男性P = 0.016 / 0.020，女性P = 0.004 / 0.012）和男性低总体QoL（P = 0.001）非线性相关。男女低SMI与高疲劳（P = 0.002）和更多疼痛（P = 0.015）显着相关，但与呼吸困难无关。所有回归分析均显示，在SMI断裂点以下，男性的身体状况较差，男性为42？45 cm 2 / m 2，女性为37 ???? 40 cm 2 / m 2。在两个性别中，PF差和呼吸困难多与SMD低有关。结论NSCLC的低肌肉质量会对患者的PF，RF和整体QoL产生负面影响，男性可能比女性影响更大。但是，在检测到这种效果之前，肌肉质量必须低于阈值。

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