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The influence of different muscle mass measurements on the diagnosis of cancer cachexia

机译：不同肌肉质量测量对癌症恶病质诊断的影响

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Abstract Background Progressive loss of muscle mass is a major characteristic of cancer cachexia. Consensus definitions for cachexia provide different options to measure muscle mass. This study describes the effect of different methods to determine muscle mass on the diagnosis of cancer cachexia. In addition, the association of cachexia with other features of cachexia, quality of life, and survival was explored. Methods Prior to chemotherapy, cachexia was assessed by weight loss, body mass index, and muscle mass measurements, the latter by mid-upper arm muscle area (MUAMA), computed tomography (CT) scans, and bio-electrical impedance analysis (BIA). In addition, appetite, inflammation, muscle strength, fatigue, quality of life, and survival were measured, and associations with cachexia were explored. Results Included were 241 patients with advanced cancer of the lung (36%), colon/rectum (31%), prostate (18%), or breast (15%). Mean age was 64 ???± 10 years; 54% was male. Prevalence of low muscle mass was as follows: 13% with MUAMA, 59% with CT, and 93% with BIA. In turn, the prevalence of cachexia was 37, 43, and 48%, whereby weight loss >5% was the most prominent component of being defined cachectic. Irrespective of type of muscle measurement, patients with cachexia presented more often with anorexia, inflammation, low muscle strength, and fatigue and had lower quality of life. Patients with cachexia had worse overall survival compared with patients without cachexia: HRs 2.00 (1.42?￠????2.83) with MUAMA, 1.64 (1.15?￠????2.34) with CT, and 1.50 (1.05?￠????2.14) with BIA. Conclusions Although the prevalence of low muscle mass in patients with cancer depended largely on the type of muscle measurement, this had little influence on the diagnosis of cancer cachexia (as the majority of patients was already defined cachectic based on weight loss). New studies are warranted to further elucidate the additional role of muscle measurements in the diagnosis of cachexia and the association with clinical outcomes.
机译：摘要背景肌肉质量的逐渐丧失是癌症恶病质的主要特征。恶病质的共识定义为测量肌肉质量提供了不同的选择。这项研究描述了确定肌肉质量的不同方法对癌症恶病质诊断的影响。此外，探讨了恶病质与恶病质，生活质量和生存期的其他特征之间的关系。方法化疗前，通过体重减轻，体重指数和肌肉质量测量评估恶病质，然后通过上臂中部肌肉区域（MUAMA），计算机断层扫描（CT）扫描和生物电阻抗分析（BIA）评估恶病质。此外，测量食欲，炎症，肌肉力量，疲劳，生活质量和生存，并探讨与恶病质的相关性。结果包括241例患有晚期肺癌（36％），结肠/直肠癌（31％），前列腺癌（18％）或乳腺癌（15％）的患者。平均年龄为64±10岁。 54％是男性。低肌肉质量的患病率如下：MUAMA为13％，CT为59％，BIA为93％。反过来，恶病质的患病率分别为37％，43％和48％，其中体重减轻> 5％是定义恶病质的最主要组成部分。无论肌肉测量的类型如何，恶病质患者更常出现厌食症，炎症，肌肉力量低下和疲劳，生活质量较低。与没有恶病质的患者相比，恶病质的患者的总生存期较差：MUAMA的HRs为2.00（1.42％）2.83，CT的HRs为1.64（1.15％）2.34，而CT为1.50（1.05％）。 2.14）用BIA。结论尽管癌症患者低肌肉质量的患病率在很大程度上取决于肌肉测量的类型，但这对癌症恶病质的诊断几乎没有影响（因为大多数患者已经根据体重减轻定义恶病质）。有必要进行新的研究，以进一步阐明肌肉测量在恶病质诊断中的附加作用以及与临床结果的关系。

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