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首页> 外文期刊>Journal of Cachexia, Sarcopenia and Muscle >Development of a bedside viable ultrasound protocol to quantify appendicular lean tissue mass
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Development of a bedside viable ultrasound protocol to quantify appendicular lean tissue mass

机译：制定床边可行的超声方案以量化阑尾瘦组织质量

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Abstract Background Ultrasound is a non-invasive and readily available tool that can be prospectively applied at the bedside to assess muscle mass in clinical settings. The four-site protocol, which images two anatomical sites on each quadriceps, may be a viable bedside method, but its ability to predict musculature has not been compared against whole-body reference methods. Our primary objectives were to (i) compare the four-site protocol's ability to predict appendicular lean tissue mass from dual-energy X-ray absorptiometry; (ii) optimize the predictability of the four-site protocol with additional anatomical muscle thicknesses and easily obtained covariates; and (iii) assess the ability of the optimized protocol to identify individuals with low lean tissue mass. Methods This observational cross-sectional study recruited 96 university and community dwelling adults. Participants underwent ultrasound scans for assessment of muscle thickness and whole-body dual-energy X-ray absorptiometry scans for assessment of appendicular lean tissue. Ultrasound protocols included (i) the nine-site protocol, which images nine anterior and posterior muscle groups in supine and prone positions, and (ii) the four-site protocol, which images two anterior sites on each quadriceps muscle group in a supine position. Results The four-site protocol was strongly associated ( R 2 = 0.72) with appendicular lean tissue mass, but Bland?￠????Altman analysis displayed wide limits of agreement (?￠????5.67, 5.67 kg). Incorporating the anterior upper arm muscle thickness, and covariates age and sex, alongside the four-site protocol, improved the association ( R 2 = 0.91) with appendicular lean tissue and displayed narrower limits of agreement (?￠????3.18, 3.18 kg). The optimized protocol demonstrated a strong ability to identify low lean tissue mass (area under the curve = 0.89). Conclusions The four-site protocol can be improved with the addition of the anterior upper arm muscle thickness, sex, and age when predicting appendicular lean tissue mass. This optimized protocol can accurately identify low lean tissue mass, while still being easily applied at the bedside.
机译：摘要背景超声是一种非侵入性且易于使用的工具，可以在床边应用，以评估临床环境中的肌肉质量。在每个股四头肌上成像两个解剖部位的四部位方案可能是一种可行的床旁方法，但尚未将其预测肌肉组织的能力与全身参考方法进行比较。我们的主要目标是（i）比较四部位方案从双能X射线吸收法预测阑尾瘦组织质量的能力; （ii）通过额外的解剖肌肉厚度和容易获得的协变量来优化四部位方案的可预测性; （iii）评估优化方案识别瘦肉组织质量低的个体的能力。方法该观察性横断面研究招募了96名大学和社区居民。参与者进行了超声扫描以评估肌肉厚度，并进行了全身双能X线吸收测定扫描以评估阑尾瘦组织。超声规程包括（i）九点规程，对仰卧位和俯卧位的九个前后肌肉群进行成像;（ii）四点规程，对四个股四头肌肌群在仰卧位的两个前位肌进行成像。结果四部位方案与阑尾瘦组织质量密切相关（R 2 = 0.72），但布兰德·奥尔特曼（Bland）Altman分析显示出一致的广泛限制（5.67，5.67 kg）。结合前臂上肌厚度，以及年龄和性别的协变量，以及四部位方案，改善了与阑尾瘦组织的关联（R 2 = 0.91），并且显示出较窄的一致极限（3.18、3.18）公斤）。优化的方案证明了识别低瘦组织质量（曲线下面积= 0.89）的强大能力。结论在预测阑尾瘦组织量时，可通过增加前臂上肌厚度，性别和年龄来改善四部位方案。这种优化的方案可以准确地识别出瘦肉组织的低质量，同时仍然可以很容易地应用于床边。

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