• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Cachexia, Sarcopenia and Muscle >Tissue sodium accumulation and peripheral insulin sensitivity in maintenance hemodialysis patients
【24h】

Tissue sodium accumulation and peripheral insulin sensitivity in maintenance hemodialysis patients

机译：维持性血液透析患者的组织钠蓄积和外周胰岛素敏感性

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract Background Recent data suggest that sodium (Na + ) is stored in the muscle and skin without commensurate water retention in maintenance hemodialysis (MHD) patients. In this study, we hypothesized that excessive Na + accumulation would be associated with abnormalities in peripheral insulin action. Methods Eleven MHD patients and eight controls underwent hyperinsulinemic?￠????euglycemic?￠????euaminoacidemic clamp studies to measure glucose (GDR) and leucine disposal rates (LDR), as well as lower left leg 23 Na magnetic resonance imaging to measure Na + concentration in the muscle and skin tissue. Results The median GDR and LDR levels were lower, and the median muscle Na + concentration was higher in MHD patients compared with controls. No significant difference was found regarding skin Na + concentration between group comparisons. Linear regression revealed inverse relationships between muscle Na + concentration and GDR and LDR in MHD patients, whereas no relationship was observed in controls. There was no association between skin Na + content and GDR or LDR in either MHD patients or controls. Conclusions These data suggest that excessive muscle Na + content might be a determinant of IR in MHD patients, although the causality and mechanisms remain to be proven.
机译：摘要背景最近的数据表明，在维持性血液透析（MHD）患者中，钠（Na +）存储在肌肉和皮肤中而没有相应的保水作用。在这项研究中，我们假设过量的Na +积累与外周胰岛素作用异常有关。方法对11名MHD患者和8名对照进行高胰岛素，正常血糖，正常血糖的研究，以测量葡萄糖（GDR）和亮氨酸清除率（LDR），以及左下腿23 Na磁共振成像测量肌肉和皮肤组织中的Na +浓度。结果与对照组相比，MHD患者的中位GDR和LDR水平较低，而肌肉中Na +浓度较高。组间比较未发现有关皮肤Na +浓度的显着差异。线性回归显示，MHD患者的肌肉Na +浓度与GDR和LDR之间呈反比关系，而在对照组中则没有相关性。 MHD患者或对照组的皮肤Na +含量与GDR或LDR之间没有关联。结论这些数据表明，尽管MHD患者的肌肉Na +含量过多可能是IR的决定因素，但其因果关系和机制尚待证实。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号