• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Cachexia, Sarcopenia and Muscle >Muscle mass as a target to reduce fatigue in patients with advanced cancer
【24h】

Muscle mass as a target to reduce fatigue in patients with advanced cancer

机译：以肌肉质量为目标，以减轻晚期癌症患者的疲劳

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract Background Cancer-related fatigue (CRF) reduces quality of life and the activity level of patients with cancer. Cancer related fatigue can be reduced by exercise interventions that may concurrently increase muscle mass. We hypothesized that low muscle mass is directly related to higher CRF. Methods A total of 233 patients with advanced cancer starting palliative chemotherapy for lung, colorectal, breast, or prostate cancer were studied. The skeletal muscle index (SMI) was calculated as the patient's muscle mass on level L3 or T4 of a computed tomography scan, adjusted for height. Fatigue was assessed with the Functional Assessment of Chronic Illness Therapy-fatigue questionnaire (cut-off for fatigue <34). Multiple linear regression analyses were conducted to study the association between SMI and CRF adjusting for relevant confounders. Results In this group of patients with advanced cancer, the median fatigue score was 36 (interquartile range 26?￠????44). A higher SMI on level L3 was significantly associated with less CRF for men (B 0.447, P 0.004) but not for women (B ?￠???? 0.401, P 0.090). No association between SMI on level T4 and the Functional Assessment of Chronic Illness Therapy-fatigue score was found ( n = 82). Conclusions The association between SMI and CRF may lead to the suggestion that male patients may be able to reduce fatigue by exercise interventions aiming at an increased muscle mass. In women with advanced cancer, CRF is more influenced by other causes, because it is not significantly related to muscle mass. To further reduce CRF in both men and women with cancer, multifactorial assessments need to be performed in order to develop effective treatment strategies.
机译：摘要背景癌症相关的疲劳（CRF）降低了癌症患者的生活质量和活动水平。可以通过同时增加肌肉质量的运动干预措施来减少与癌症相关的疲劳。我们假设低肌肉质量与较高的CRF直接相关。方法对总共233例开始姑息性化疗的肺癌，大肠癌，乳腺癌或前列腺癌的晚期癌症患者进行了研究。骨骼肌指数（SMI）是在计算机X线断层扫描的L3或T4级别上根据患者的肌肉质量进行计算的，并调整了身高。疲劳通过慢性病治疗疲劳功能问卷进行评估（疲劳临界值<34）。进行了多元线性回归分析，以研究针对相关混杂因素调整的SMI和CRF之间的关联。结果在这组晚期癌症患者中，中位疲劳评分为36（四分位数范围为26？44）。 L3水平上较高的SMI与男性的CRF较低显着相关（B 0.447，P = 0.004），而女性的CRF较低（B≥0.401，P 0.090）。在T4级的SMI与慢性病治疗疲劳评分的功能评估之间未发现关联（n = 82）。结论SMI和CRF之间的关联可能导致男性患者可以通过针对肌肉增加的运动干预来减轻疲劳。在患有晚期癌症的女性中，CRF受其他原因的影响更大，因为它与肌肉质量没有明显关系。为了进一步降低男性和女性癌症的CRF，需要进行多因素评估以制定有效的治疗策略。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号