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首页> 外文期刊>Journal of Cachexia, Sarcopenia and Muscle >Combined approach to counteract experimental cancer cachexia: eicosapentaenoic acid and training exercise
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Combined approach to counteract experimental cancer cachexia: eicosapentaenoic acid and training exercise

机译：对抗实验性癌症恶病质的联合方法：二十碳五烯酸和训练运动

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BackgroundCancer cachexia is a syndrome characterized by loss of skeletal muscle protein, depletion of lipid stores, anorexia, weakness, and perturbations of the hormonal homeostasis. Despite several therapeutic approaches described in the past, effective interventions countering cancer cachexia are still lacking.MethodsThe present work was aimed to verify the ability of eicosapentaenoic acid (EPA) to prevent the muscle depletion in Lewis lung carcinoma-bearing mice and to test the ability of endurance exercise training to increase the EPA effect.ResultsEPA alone did not prevent the muscle loss induced by tumor growth while the combination with exercise induced a partial rescue of muscle strength and mass. Moreover, the association of EPA and exercise reduced the dramatic PAX-7 accumulation and stimulated the increase of PCG-1 protein.ConclusionsOverall, the present data suggest that exercise is an effective tool that should be added for combined therapeutic approaches against cancer cachexia.
机译：背景癌症恶病质是一种以骨骼肌蛋白丢失，脂质存储耗尽，厌食，虚弱和荷尔蒙稳态紊乱为特征的综合征。尽管过去描述了几种治疗方法，但仍缺乏针对癌症恶病质的有效干预措施。方法本工作旨在验证二十碳五烯酸（EPA）预防Lewis肺癌小鼠肌肉衰竭的能力并测试该能力结果单独使用EPA并不能防止肿瘤生长引起的肌肉丢失，而与运动相结合可以部分地挽救肌肉的力量和质量。此外，EPA与运动的结合减少了PAX-7的大量积聚并刺激了PCG-1蛋白的增加。结论总的来说，目前的数据表明运动是一种有效的工具，应被用于治疗恶病质的综合治疗方法。

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