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首页> 外文期刊>Journal of Cachexia, Sarcopenia and Muscle >Cancer cachexia and anabolic interventions: a case report
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Cancer cachexia and anabolic interventions: a case report

机译：癌症恶病质和合成代谢干预：一例报告

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BackgroundStandard-of-care (SOC) cancer treatments are primarily aimed at reducing size and progression of a tumor. There is a need for successful supplemental anabolic therapies to combat cancer cachexia in addition to these SOC treatment modalities. Anabolic interventions, including testosterone and amino acid supplements, may be beneficial in reducing and/or reversing muscle wasting in these patient populations.MethodsA 48-year-old Caucasian female with recurrent cervical cancer was scheduled to receive three 21-day cycles of cisplatin and topetecan chemotherapy. She qualified, consented, and enrolled into a blinded interventional pilot study where she received daily whey protein (10?g, three times per day with meals) and a weekly injection of testosterone enanthate (100?mg intramuscular) before and during the SOC chemotherapy treatment period. Body composition, serum inflammatory markers, mixed muscle protein synthesis and breakdown rates, physical function, fatigue, and quality of life were assessed before and after the intervention period.ResultsBody composition, as assessed by an increase in body weight and lean body mass and reduction in fat mass; physical function; fatigue; and quality of life each improved across the entire intervention period despite general increases in inflammatory markers and no improvements in muscle protein turnover towards the end of the intervention.ConclusionsConcomitant treatment of oral amino acids and testosterone may be a viable therapeutic option for fighting cachexia and improving body composition and quality of life during chemotherapeutic treatment of recurrent cervical cancer. These positive outcomes may be attainable over time despite overall poor inflammatory status.
机译：背景技术护理标准（SOC）的癌症治疗主要旨在减少肿瘤的大小和进展。除了这些SOC治疗方式以外，还需要成功的补充合成代谢疗法来对抗癌症恶病质。方法包括睾丸激素和氨基酸补充剂在内的合成代谢干预措施可能对减少和/或逆转这些患者人群的肌肉消瘦有益。方法：一名患有复发性宫颈癌的48岁白人女性计划接受三个21天的顺铂和拓普替康化疗。她获得了资格，同意并参加了一项盲目的干预性试验研究，在SOC化疗之前和期间，她每天接受乳清蛋白（10微克，一日三餐），每周注射一次睾丸酮庚酸酯（肌内100微毫克）。治疗期。在干预期间之前和之后评估身体组成，血清炎症标志物，混合肌蛋白的合成和分解率，身体功能，疲劳和生活质量。结果通过增加体重和瘦体重以及减少体重来评估身体组成脂肪量身体机能疲劳;尽管炎症标志物普遍增加并且在干预结束时肌肉蛋白更新没有改善，但整个干预期间的生活质量和生活质量均得到改善。复发性子宫颈癌的化学治疗期间的身体成分和生活质量。尽管总体上炎症状态较差，但随着时间的推移，这些积极的结果仍可实现。

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