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首页> 外文期刊>Journal of Cachexia, Sarcopenia and Muscle >Cachexia-associated adipose tissue morphological rearrangement in gastrointestinal cancer patients
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Cachexia-associated adipose tissue morphological rearrangement in gastrointestinal cancer patients

机译：恶病质与胃肠道肿瘤患者脂肪组织形态重排

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Abstract Background and aims Cachexia is a syndrome characterized by marked involuntary loss of body weight. Recently, adipose tissue (AT) wasting has been shown to occur before the appearance of other classical cachexia markers. We investigated the composition and rearrangement of the extracellular matrix, adipocyte morphology and inflammation in the subcutaneous AT (scAT) pad of gastrointestinal cancer patients. Methods Surgical biopsies for scAT were obtained from gastrointestinal cancer patients, who were signed up into the following groups: cancer cachexia (CC, n = 11), weight-stable cancer (WSC, n = 9) and weight-stable control (non-cancer) (control, n = 7). The stable weight groups were considered as those with no important weight change during the last year and body mass index <25 kg/m 2 . Subcutaneous AT fibrosis was quantified and characterized by quantitative PCR, histological analysis and immunohistochemistry. Results The degree of fibrosis and the distribution and collagen types (I and III) were different in WSC and CC patients. CC patients showed more pronounced fibrosis in comparison with WSC. Infiltrating macrophages surrounding adipocytes and CD3 Ly were found in the fibrotic areas of scAT. Subcutaneous AT fibrotic areas demonstrated increased monocyte chemotactic protein 1 (MCP-1) and Cluster of Differentiation (CD)68 gene expression in cancer patients. Conclusions Our data indicate architectural modification consisting of fibrosis and inflammatory cell infiltration in scAT as induced by cachexia in gastrointestinal cancer patients. The latter was characterized by the presence of macrophages and lymphocytes, more evident in the fibrotic areas. In addition, increased MCP-1 and CD68 gene expression in scAT from cancer patients may indicate an important role of these markers in the early phases of cancer.
机译：摘要背景与目的恶病质是一种以体重明显减轻为特征的综合症。最近，已经证明脂肪组织（AT）的浪费发生在其他经典恶病质标志物出现之前。我们调查了胃肠道癌症患者皮下AT（scAT）垫中的细胞外基质，脂肪细胞形态和炎症的组成和重排。方法从胃肠道恶性肿瘤患者中获取针对scAT的手术活检，将其分为以下几类：恶病质（CC，n = 11），体重稳定的癌症（WSC，n = 9）和体重稳定的对照（非肥胖）。癌症）（对照组，n = 7）。稳定体重组被认为是在过去一年中体重没有重大变化且体重指数<25 kg / m 2的那些。通过定量PCR，组织学分析和免疫组织化学对皮下AT纤维化进行定量和表征。结果WSC和CC患者的纤维化程度，分布和胶原类型（I和III）不同。与WSC相比，CC患者的纤维化更为明显。在scAT的纤维化区域发现了周围脂肪细胞和CD3 Ly浸润的巨噬细胞。皮下AT纤维化区域显示癌症患者单核细胞趋化蛋白1（MCP-1）和分化簇（CD）68基因表达增加。结论我们的数据表明，胃肠道恶性肿瘤患者恶病质所致，scAT中的纤维化和炎性细胞浸润构成了结构修饰。后者的特征是存在巨噬细胞和淋巴细胞，在纤维化区域更为明显。另外，来自癌症患者的scAT中MCP-1和CD68基因表达的增加可能表明这些标记物在癌症的早期阶段起着重要的作用。

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