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首页> 外文期刊>Journal of American physicians and surgeons / >Fetal Therapy for Down Syndrome: Report of Three Cases and a Review of the Literature
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Fetal Therapy for Down Syndrome: Report of Three Cases and a Review of the Literature

机译：唐氏综合症的胎儿疗法：三例报告并文献复习

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The relative importance of biology (nature) and experience (nurture) in brain development has long been debated in science, medicine, and philosophy.Over the years, ample evidence has accumulated to support key roles for both nature and nurturing. Therefore, if one assumes the point of view that both are important, effective therapeutic interventions aimed at enhancing brain development should be based on both biology and experience.At the 69th AAPS meeting (2012), the “five-square” protocol was proposed for Down syndrome, other developmental disorders, and for normal children. This protocol should include biomedical treatments before and after birth; educational treatments before and after birth; and breastfeeding, which is both experiential and biochemical in nature.Brain development could be viewed as a therapeutically modifiable process. This report will discuss several clinical cases that approximate the “five-square” treatment strategy in children with Down syndrome. Research with trisomic mouse models of Down syndrome has begun to elucidate how Down syndrome affects brain development. Recent results published in the literature show that, at least in treated mice, correcting the problems early in development can result in improved neurologic performance.
机译：生物学（自然）和经验（培养）在大脑发育中的相对重要性在科学，医学和哲学领域一直存在争议。多年来，已经积累了足够的证据来支持自然和养育的关键作用。因此，如果认为两者都很重要，则旨在促进大脑发育的有效治疗干预措施应基于生物学和经验。在第69届AAPS会议（2012年）上，提出了“五平方”协议唐氏综合症，其他发育障碍以及正常儿童。该方案应包括出生前后的生物医学治疗;出生前后的教育治疗;和母乳喂养，这既是实验性的又是生物化学方法。该报告将讨论唐氏综合症患儿的近似“五平方”治疗策略的几种临床病例。对唐氏综合症的三体小鼠模型的研究已开始阐明唐氏综合症如何影响大脑发育。文献中发表的最新结果表明，至少在治疗的小鼠中，纠正发育早期的问题可以导致神经功能的改善。

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