Fascin expression is inversely correlated with breast cancer metastasis suppressor 1 and predicts a worse survival outcome in node-negative breast cancer patients

Hye Jin Lee; Hee Jung An; Tae Hoen Kim; Gwangil Kim; Haeyoun Kang; Jin Hyung Heo; Ah-Young Kwon; Sewha Kim

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Fascin expression is inversely correlated with breast cancer metastasis suppressor 1 and predicts a worse survival outcome in node-negative breast cancer patients

机译：Fascin表达与乳腺癌转移抑制因子1呈负相关，并预测淋巴结阴性乳腺癌患者的生存结果更差

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Background: Fascin is an actin-bundling protein that promotes cancer cell migration and invasion. By contrast, breast cancer metastasis suppressor 1 (BRMS1) inhibits cancer metastasis by targeting multiple steps of the metastatic cascade. We evaluated whether expression patterns of fascin and BRMS1 correlate with clinicopathological features and patient outcome.

机译：背景：Fascin是一种肌动蛋白捆绑蛋白，可促进癌细胞迁移和侵袭。相比之下，乳腺癌转移抑制因子1（BRMS1）通过靶向转移级联的多个步骤来抑制癌症转移。我们评估了fascin和BRMS1的表达模式是否与临床病理特征和患者预后相关。

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《Journal of Cancer》 |2017年第16期|共8页
作者
Hye Jin Lee; Hee Jung An; Tae Hoen Kim; Gwangil Kim; Haeyoun Kang; Jin Hyung Heo; Ah-Young Kwon; Sewha Kim;
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中图分类肿瘤学;
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专利

1. Fascin expression is inversely correlated with breast cancer metastasis suppressor 1 and predicts a worse survival outcome in node-negative breast cancer patients [J] . Hye Jin Lee, Hee Jung An, Tae Hoen Kim, Journal of Cancer . 2017,第16期

机译：Fascin表达与乳腺癌转移抑制因子1呈负相关，并预测淋巴结阴性乳腺癌患者的生存结果更差
2. Breast cancer metastasis suppressor 1 (BRMS1) suppresses metastasis and correlates with improved patient survival in non-small cell lung cancer. [J] . Smith PW, Liu Y, Siefert SA, Cancer letters . 2009,第2期

机译：乳腺癌转移抑制因子1（BRMS1）抑制转移，并与非小细胞肺癌患者的生存改善相关。
3. A prospective, multicenter validation study of a prognostic index composed of S-phase fraction, progesterone receptor status, and tumour size predicts survival in node-negative breast cancer patients: NNBC, the node-negative breast cancer trial [J] . Klintman M., Nilsson F., Bendahl P. -O., Annals of oncology: official journal of the European Society for Medical Oncology . 2013,第9期

机译：一种预期的多中心验证研究，由S相级分，孕酮受体状态和肿瘤大小预测节点阴性乳腺癌患者的存活：NNBC，节点阴性乳腺癌试验
4. COMPUTER-AIDED PROGNOSIS OF ER+ BREAST CANCER HISTOPATHOLOGY AND CORRELATING SURVIVAL OUTCOME WITH ONCOTYPE DX ASSAY [C] . Ajay Basavanhally, Jun Xu, Anant Madabhushi, IEEE International Symposium on Biomedical Imaging . 2009

机译：ER +乳腺癌组织病理学的计算机辅助预后和腹型DX测定的相关生存结果
5. Genetic variation and protein expression of metastasis-related genes as markers of tumor aggressiveness, recurrence, and survival among breast cancer patients. [D] . Roberts, Michelle R. 2016

机译：转移相关基因的遗传变异和蛋白质表达是乳腺癌患者肿瘤侵袭性，复发和生存的标志。
6. Fascin expression is inversely correlated with breast cancer metastasis suppressor 1 and predicts a worse survival outcome in node-negative breast cancer patients [O] . Hye Jin Lee, Hee Jung An, Tae Hoen Kim, 2017

机译：Fascin表达与乳腺癌转移抑制因子1呈负相关并预测淋巴结阴性乳腺癌患者的生存结果更差
7. Fascin expression is inversely correlated with breast cancer metastasis suppressor 1 and predicts a worse survival outcome in node-negative breast cancer patients [O] . Hye Jin Lee, Hee Jung An, Tae Hoen Kim, 2017

机译：Fascin表达与乳腺癌转移抑制剂1与乳腺癌转移抑制剂1相反，并预测节点阴性乳腺癌患者中的更糟糕的存活结果
8. Expression of Proteins Involved in Epithelial-Mesenchymal Transition as Predictors of Metastasis and Survival in Breast Cancer Patients. [R] . Roberts, M., Bshara, W., Higgins, M., 2015

机译：表达上皮 - 间质转化相关蛋白作为乳腺癌转移和存活的预测因子。

Fascin expression is inversely correlated with breast cancer metastasis suppressor 1 and predicts a worse survival outcome in node-negative breast cancer patients

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