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首页> 外文期刊>Journal of Cachexia, Sarcopenia and Muscle >1-Sarcosine–angiotensin II infusion effects on food intake, weight loss, energy expenditure, and skeletal muscle UCP3 gene expression in a rat model
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1-Sarcosine–angiotensin II infusion effects on food intake, weight loss, energy expenditure, and skeletal muscle UCP3 gene expression in a rat model

机译：1-Sarcosine-血管紧张素II输注对大鼠模型中食物摄入，体重减轻，能量消耗和骨骼肌UCP3基因表达的影响

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BackgroundThere are a myriad of proteins responsible for modulation of expenditure of energy. Angiotensin II (Ang II) is a vital component of renin-angiotensin system that affects blood pressure and also linked to both cachexia and obesity via fat and muscle metabolism. Previous research suggests that the direct action of Ang II is on the brain, via angiotensin II type 1 receptor protein, affecting food intake and energy expenditure. The objective of the study is to investigate the effect of 1-sarcosine (SAR)-Ang II infusion on energy expenditure and metabolism in a rat model of congestive heart failure cachexia.MethodsAdult female rats of the Sprague Dawley strain (n?=?33) were used (11 pair-fed control, 12 ad libitum and 10, 1-sarcosine–angiotensin II-infused rats). Body weight, faecal excretion, feed intake (in grams), water intake (in milliliters) and urine excreted were recorded daily. The measurements were recorded in three different periods (4?days prior to surgery, “pre-infusion”; day of surgery and 5?days postsurgery, “infusion period”; days 7 to 14, “recovery” period). Different analytical methods were used to measure energy expenditure per period, uncoupling protein 3 mRNA expression, crude protein and adipose tissue body composition.ResultsDuring the infusion period, the SAR–Ang II group experienced rapid weight loss (p?
机译：背景技术有无数种蛋白质可调节能量消耗。血管紧张素II（Ang II）是肾素-血管紧张素系统的重要组成部分，它影响血压，并通过脂肪和肌肉代谢与恶病质和肥胖症相关。先前的研究表明，Ang II的直接作用是通过血管紧张素II 1型受体蛋白作用于大脑，从而影响食物摄入和能量消耗。本研究的目的是研究1-肌氨酸（SAR）-Ang II输注对充血性心力衰竭恶病质大鼠模型中能量消耗和代谢的影响。 ）（11对喂食的对照，12只随意喂养的动物和10只注入1-肌氨酸-血管紧张素II的大鼠）。每天记录体重，粪便排泄，饲料摄入（以克为单位），水摄入（以毫升为单位）和尿液排泄。在三个不同的时期内记录测量值（手术前4天，“输液前”;手术日和手术后5天，“输液期”;第7至14天，“恢复”期）。使用不同的分析方法来测量每个时期的能量消耗，解偶联蛋白3 mRNA表达，粗蛋白和脂肪组织的身体成分。结果在输注期间，SAR-Ang II组的体重迅速减轻（p <0.05），与之相比随随便便和成对喂食的人群。 SAR-Ang II组的体脂含量（％）低于对照组（p <0.05）。与对照组相比，SAR–Ang II组和成对进食组的解偶联蛋白3（UCP3）mRNA表达也增加（p？<？0.05）。结论总而言之，结果表明SAR–Ang II输注受损。食欲不振，主要是通过浪费脂肪组织来减轻体重，这可能是由于线粒体解偶联（UCP3蛋白活性）导致能量消耗增加所致。

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