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首页> 外文期刊>Journal of Cardio-Thoracic Medicine >The Relationship between Serum Pro‐Brain Natriuretic Peptide (Pro‐BNP) Levels and Pulmonary Arterial Hypertension (PAH) in Patients with Limited Scleroderma
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The Relationship between Serum Pro‐Brain Natriuretic Peptide (Pro‐BNP) Levels and Pulmonary Arterial Hypertension (PAH) in Patients with Limited Scleroderma

机译：硬皮病患者血清前脑利钠肽（Pro-BNP）水平与肺动脉高压（PAH）之间的关系

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Introduction: Pulmonary arterial hypertension (PAH) is a late progressive sclerodermarelated complication, which can lead to right heart failure and cor pulmonale. Given that cardiac catheterization is a diagnostic method of choice for PAH, and considering the high risks of this method, the purpose of this study was to evaluate the relationship between serum Pro‐Brain natriuretic peptide (Pro‐BNP) Levels and PAH in patients with limited scleroderma. Materials and Methods: In this cross sectional study , during June 2011‐ Dec 2013, referring patients to two major educational hospitals, Mashhad‐ Iran, with scleroderma, who were afflicted with the disease for at least two years (or more), were enrolled in the study if they met the inclusion and exclusion criteria. All the patients underwent echocardiography to determine the pulmonary artery pressure (PAP). Afterwards, the subjects were referred to a lung center for performing body plethysmography, carbon monoxide diffusing capacity (DLCO), and 6‐ minute walk test (6MWT). Pro‐BNP Serum level was determined using flourescent immune assay method. Results: The present study included 20 patients (18 female subjects) with the mean age of 43.28±9.56 yrs, and the mean pro‐BNP level of 138 pg/ml. The logarithmic correlation between PAP values, Forced Vital Capacity /DLCO ratio, and pro‐BNP level, which was measured using Pearson's correlation coefficient, showed a significant association among these variables( respectively, r=0.76, P?0.001; r=0.677, P=0.011). Moreover, the DLCO decrease was associated with increasing pro‐BNP level, though this relationship was not significant. Conclusion: This study showed that there was a significant relationship between the serum levels of pro‐BNP marker and increased PAP in the echocardiography, DLCO reduction, and FVC/DLCO increase. In fact, this serum marker can be used in patients with systemic scleroderma (SSc) to evaluate the status of PAH.
机译：简介：肺动脉高压（PAH）是晚期进行性硬皮病相关的并发症，可导致右心衰竭和肺心病。鉴于心脏导管检查是选择PAH的一种诊断方法，并且考虑到该方法的高风险性，本研究的目的是评估血清前脑利钠肽（Pro-BNP）水平与PAH患者PAH之间的关系。局限性硬皮病。材料和方法：在这项横断面研究中，于2011年6月至2013年12月期间，将患者转诊至两家患有疾病至少两年（或更长时间）的硬皮病的主要医院，即Mashhad-Iran。在研究中是否符合纳入和排除标准。所有患者均接受超声心动图检查以确定肺动脉压（PAP）。之后，将受试者转至肺部进行体体积描记，一氧化碳扩散能力（DLCO）和6分钟步行测试（6MWT）。前BNP血清水平使用荧光免疫测定法确定。结果：本研究包括20名患者（18名女性受试者），平均年龄为43.28±9.56岁，平均pro-BNP水平为138 pg / ml。使用Pearson相关系数测量的PAP值，强制肺活量/ DLCO比值和pro-BNP水平之间的对数相关性显示，这些变量之间存在显着相关性（分别为r = 0.76，P？0.001，r = 0.677， P ＝ 0.011）。此外，DLCO降低与前BNP水平升高有关，尽管这种关系并不明显。结论：这项研究表明，超声心动图中血清前BNP标记水平与PAP升高，DLCO降低和FVC / DLCO升高之间存在显着相关性。实际上，该血清标志物可用于全身性硬皮病（SSc）患者以评估PAH的状态。

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