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首页> 外文期刊>Journal of Cancer >A Retrospective Cohort Study of Nasopharyngeal Carcinoma Screening and Hepatocellular Carcinoma Screening in Zhongshang City
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A Retrospective Cohort Study of Nasopharyngeal Carcinoma Screening and Hepatocellular Carcinoma Screening in Zhongshang City

机译：中山市鼻咽癌筛查与肝细胞癌筛查回顾性队列研究

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Background: Nasopharyngeal carcinoma (NPC) and hepatocellular carcinoma (HCC) have remained a major burden of public health in Southern China. The screening for early disease in asymptomatic individuals has potentially been the most promising tool to improve cancer treatment outcomes. The present study aims to evaluate the compliance rates and characteristics of cancer incidence in the population of NPC and HCC screening. Methods: Enzyme-linked immunsorbent assay (ELISA) for Epstein-Barr virus (EBV) antibodies and Hepatitis B surface antigen (HBsAg) was performed in this population. NPC high/medium risk and HCC high risk individuals were followed-up for a number of years. The compliance rate, cancer incidence and early diagnosis rate of the screened population were statistically analyzed. Results: (1) In the preliminary screening, the compliance rate for NPC screening was significantly higher than that for HCC screening (29.3% vs. 26.2%; P 0.05). The compliance rates for screening were positively associated with age in these two screenings ( P 0.01). (2) In the NPC screening, the compliance rates for the first year follow-up among NPC high/medium risk individuals were 74.9%, which was higher than that (60.2%) for the second year follow-up ( P 0.05). The compliance rates for fiberoptic endoscopy among high risk individuals decreased along with the frequency of screening ( P 0.016). The rates of missed diagnosis by non-compliance and the poor diagnostic accuracy of indicators were 3.3% and 3.3%, respectively. The average annual incidence and early diagnosis rate of the compliers were higher than those of the non-compliers (94.3 per 100,000 vs. 29.0 per 100,000; P 0.05 and 77.8% vs. 18.5%; P 0.05). (3) In the preliminary HCC screening, the compliance rate for ultrasonography among high risk individuals was 61.8%. The compliance rates for the follow-up were unsatisfactory. The rates of missed diagnosis by non-compliance and the poor diagnostic accuracy of indicators were 12.3% and 24.6%, respectively. There was no significant differences in average annual incidence and the rate of early diagnosis between compliers and non-compliers (79.4 per 100,000 vs. 54.6 per 100,000, P 0.05; 49.1% vs. 38.5%, P 0.05). Conclusion: The compliance rates for NPC and HCC screening needs to be improved. In particular, public health policies for HCC should be implemented. The present NPC screening could be the preferred strategy. However, the efficiency of HCC screening remains substantially unsatisfactory and needs to be further discussed.
机译：背景：鼻咽癌（NPC）和肝细胞癌（HCC）仍然是中国南方公共卫生的主要负担。对无症状个体进行早期疾病筛查可能是改善癌症治疗结果的最有希望的工具。本研究旨在评估NPC和HCC筛查人群中癌症发生率的依从率和特征。方法：对该人群进行了爱泼斯坦-巴尔病毒（EBV）抗体和乙型肝炎表面抗原（HBsAg）的酶联免疫吸附测定（ELISA）。对NPC高/中危和HCC高危人群进行了多年随访。统计分析筛查人群的依从率，癌症发生率和早期诊断率。结果：（1）在初步筛查中，NPC筛查的依从率显着高于HCC筛查的依从率（29.3％对26.2％; P <0.05）。在这两次筛查中筛查的依从率与年龄呈正相关（P <0.01）。 （2）在全国人大筛查中，全国人大高中危人群第一年随访的依从率为74.9％，高于第二年随访的（60.2％）（P <0.05） 。高危人群中纤维内窥镜检查的依从率随着筛查频率的降低而降低（P <0.016）。不符合项导致的漏诊率和指标的诊断准确性差，分别为3.3％和3.3％。编纂者的年平均发病率和早期诊断率高于未编撰者（94.3 / 100,000对29.0 / 10万; P <0.05和77.8％对18.5％; P <0.05）。 （3）在初步的HCC筛查中，高危人群超声检查的依从率为61.8％。随访的依从率不令人满意。不符合项导致的漏诊率和指标的诊断准确性差，分别为12.3％和24.6％。符合标准者和不符合标准者之间的平均年发病率和早期诊断率没有显着差异（分别为100,000和70.4，分别为100,000和54.6，P> 0.05; 49.1％和38.5％，P> 0.05）。结论：NPC和HCC筛查的依从率有待提高。特别是，应该执行针对HCC的公共卫生政策。当前的NPC筛查可能是首选策略。但是，HCC筛查的效率仍然不能令人满意，需要进一步讨论。

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