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首页> 外文期刊>Journal of Cancer Research and Therapeutics >Enhancing the longevity of three-dimensional dose in a diffusion-controlled Fricke gel dosimeter
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Enhancing the longevity of three-dimensional dose in a diffusion-controlled Fricke gel dosimeter

机译：在扩散控制的Fricke凝胶剂量计中提高三维剂量的寿命

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Introduction: The principle of Fricke gel dosimeter is the oxidation of ferric ions on exposure to radiation. The major limitation in this dosimeter is the post-irradiation diffusion of ferric ions leading to degradation of spatial dose information. Aims and Objectives: The primary objective of this study is to reduce diffusion of ferric ions post-irradiation and enhance the spatial stability of the dose for an acceptable period, within which it can be read out. Materials and Methods: A novel method has been proposed to achieve this aim by incorporation of an anti-oxidant in the present Fricke gel dosimeter. The modified gel prepared in this study consisted of 50 mM sulfuric acid, 0.05 mM xylenol orange, 0.5 mM ferrous ammonium sulfate, and an optimal concentration of anti-oxidant. Different concentrations of the anti-oxidant (ascorbic acid and glycine) based gel dosimeters were prepared. The performance evaluations of the same were characterized dosimetrically with high energy photons (x- and gamma rays). Spectrophotometric measurements of gel dosimeters were performed at a wavelength of 585 nm and the post-irradiation diffusion was studied by observing the dose response over time. The spatial dose information from the large volume cylindrical gel phantoms was acquired using an in-house optical computed tomography scanner. Results: Auto-oxidation and diffusion were controlled in the enhanced Fricke gel dosimeter by the incorporation of glycine as anti-oxidant. The post-irradiation dose in the gel dosimeter was stable up to 6 hours, thereby enhancing the longevity of three-dimensional (3D) dose. Conclusion: The widely established limitations of Fricke gel dosimeter viz., auto-oxidation and diffusion were overcome using a novel method that incorporated optimal quantity of glycine as a suitable anti-oxidant. This modified Fricke gel dosimeter could be used as an effective 3D dosimeter for practical applications in radiotherapy.
机译：简介：Fricke凝胶剂量计的原理是暴露于辐射下时三价铁离子的氧化。该剂量计的主要限制是辐射后铁离子的扩散导致空间剂量信息的降低。目的和目的：这项研究的主要目的是减少辐照后三价铁离子的扩散，并在可接受的时间内增强剂量的空间稳定性，在此时间内可以读出剂量。材料和方法：已经提出了通过在本弗里克凝胶剂量计中掺入抗氧化剂来实现该目的的新颖方法。本研究中制备的改性凝胶由50 mM硫酸，0.05 mM二甲酚橙，0.5 mM硫酸亚铁铵和最佳浓度的抗氧化剂组成。制备了不同浓度的基于抗氧化剂（抗坏血酸和甘氨酸）的凝胶剂量计。用高能光子（x射线和γ射线）以剂量学方式表征了该激光器的性能。凝胶剂量计的分光光度测量是在585 nm的波长下进行的，并且通过观察随时间的剂量响应来研究辐照后的扩散。使用内部光学计算机断层扫描仪获取大体积圆柱体凝胶体模的空间剂量信息。结果：通过加入甘氨酸作为抗氧化剂，在增强的Fricke凝胶剂量计中控制了自氧化和扩散。凝胶剂量计中的辐照后剂量在长达6小时内保持稳定，从而提高了三维（3D）剂量的寿命。结论：使用新方法将最佳量的甘氨酸作为合适的抗氧化剂，克服了Fricke凝胶剂量计的局限性，即自动氧化和扩散。这种改进的Fricke凝胶剂量计可以用作放射治疗中实际应用的有效3D剂量计。

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