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首页> 外文期刊>Journal of Cancer Research and Therapeutics >Influence of selenium on radiogenic collagen destruction and the degree of collagen tissue maturation in stage III oral squamous cell carcinoma patients undergoing therapeutic irradiation
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Influence of selenium on radiogenic collagen destruction and the degree of collagen tissue maturation in stage III oral squamous cell carcinoma patients undergoing therapeutic irradiation

机译：硒对III期口腔鳞状细胞癌放射治疗中放射胶原破坏和胶原组织成熟程度的影响

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Introduction: We set out to assess whether selenium, an antioxidant mineral could influence radiogenic collagen maturation. Materials and Methods: The study comprise of normal (Group I), untreated oral carcinoma cases (Group II) (n = 20), cases who underwent radiotherapy (Group IIa) n = 10 and cases supplemented with selenium along with radiotherapy (Group IIb) n = 10. Results: Spectrophotometric estimation and luminescence spectral assignment of collagen showed improved collagen maturation status. Measurement of the mature collagen cross-links hydroxylysylpyridinoline and lysylpyridinoline by high-performance liquid chromatography on irradiated tissues showed a considerable decrease in the selenium Group IIb (P Discussion: The results represent the effect of selenium treatment with a bearing on carcinogenic process to curtail it, thus enhancing the maturity of collagen.
机译：简介：我们着手评估硒（一种抗氧化剂矿物）是否会影响放射源性胶原蛋白的成熟。材料和方法：本研究包括正常（I组），未经治疗的口腔癌病例（II组）（n = 20），接受放射治疗的病例（IIa组）n = 10和补充硒并放疗的硒病例（IIb组） ）n =10。结果：胶原的分光光度估算和发光光谱分配显示了胶原成熟状态的改善。高效液相色谱法在辐照组织上测量成熟的胶原蛋白交联的羟基吡啶基吡啶啉和赖氨基吡啶啉显示硒IIb组显着减少（P讨论：结果代表了硒处理与致癌过程有关的抑制作用） ，从而增强胶原蛋白的成熟度。

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