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首页> 外文期刊>Journal of Cancer Research and Therapeutics >Prognostic factors of patients who received chemotherapy after cranial irradiation for non-small cell lung cancer with brain metastases: A retrospective analysis of multicenter study (Anatolian Society of Medical Oncology)
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Prognostic factors of patients who received chemotherapy after cranial irradiation for non-small cell lung cancer with brain metastases: A retrospective analysis of multicenter study (Anatolian Society of Medical Oncology)

机译：非小细胞肺癌伴脑转移的颅内照射后接受化疗的患者的预后因素：多中心研究的回顾性分析（Anatolian Medical Oncology）

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Purpose: Almost half of all patients diagnosed with non-small cell lung cancer (NSCLC) have distant metastases at presentation. One-third of patients with NSCLC will have brain metastases. Without effective treatment, the median survival is only 1 month. However, it is difficult to treat brain metastases with systemic chemotherapy since the agents have difficulty crossing the blood-brain barrier. Therefore, it is important to estimate the patient's survival prognosis. The aim of this study was to analyze prognostic factors for survival in Turkish patients who received chemotherapy after cranial irradiation for NSCLC with brain metastases. Methods: We retrospectively reviewed 698 patients with brain metastases resulting from NSCLC. Ten potential prognostic variables were chosen for analysis. Univariate and multivariate analyses were conducted to identify prognostic factors associated with overall survival (OS). Results: Among the 10 variables for univariate analysis, six were identified to have prognostic significance; these included sex, smoking history, histology, number of brain metastases, extracranial metastases, and neurosurgical resection. Multivariate analysis by the Cox proportional hazard model showed that a smoking history, extracranial metastases, and neurosurgical resection were independent negative prognostic factors for OS. Conclusion: Smoking history, extracranial metastases, and neurosurgical resection were considered independent negative prognostic factors for OS. These findings may facilitate pretreatment prediction of survival and can be used for selecting patients for more appropriate treatment options.
机译：目的：在诊断为非小细胞肺癌（NSCLC）的所有患者中，几乎有一半在就诊时有远处转移。三分之一的非小细胞肺癌患者会发生脑转移。没有有效的治疗，中位生存期仅为1个月。但是，由于这些药物难以穿越血脑屏障，因此很难通过全身化疗来治疗脑转移瘤。因此，评估患者的生存预后很重要。本研究的目的是分析接受颅脑放疗的NSCLC伴脑转移的颅骨放化疗后接受化疗的土耳其患者的生存预后因素。方法：我们回顾性分析了698例由NSCLC引起的脑转移的患者。选择十个潜在的预后变量进行分析。进行单因素和多因素分析以鉴定与总生存期（OS）相关的预后因素。结果：在用于单变量分析的10个变量中，有6个具有预后意义。这些包括性，吸烟史，组织学，脑转移瘤的数量，颅外转移瘤和神经外科切除术。通过Cox比例风险模型进行的多变量分析显示，吸烟史，颅外转移灶和神经外科切除术是OS的独立阴性预后因素。结论：吸烟史，颅外转移灶和神经外科切除被认为是OS的独立阴性预后因素。这些发现可能有助于对生存期进行预处理预测，并可用于选择患者以选择更合适的治疗方案。

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