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首页> 外文期刊>Journal of Cancer Research and Therapeutics >Association between Krüppel like factor 6 intervening sequence 1-27 G > A and cancer susceptibility: A meta-analysis
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Association between Krüppel like factor 6 intervening sequence 1-27 G > A and cancer susceptibility: A meta-analysis

机译：Krüppel样因子6干预序列1-27 G> A与癌症易感性之间的关联：一项荟萃分析

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Background/Objective: It has been reported that Krüppel like factor 6 intervening sequence (KLF6 IVS) 1-27 G > A might be associated with cancer susceptibility. Here, we conducted a meta-analysis to summarize and clarify this association. Materials and Methods/Main Results: A systematic search of studies on the association between KLF6 IVS 1-27 G > A, and cancer susceptibility was conducted in databases. Odds ratios and 95% confidence intervals were used to pool the effect size. Seven articles were included in our meta-analysis. Overall and in prostate cancer, population-based subgroup overall and Caucasian subgroup overall, no evidence was found for the association between KLF6 IVS 1-27 G > A polymorphism and cancer susceptibility in any genetic model and the results showed stability in sensitivity analyses. Conclusions: KLF6 IVS 1-27 G > A may not be associated with cancer susceptibility, especially the susceptibility of unselected prostate cancer. However, there was insufficient data to fully confirm the association between KLF6 IVS 1-27 G > A and familial prostate cancer, sporadic prostate cancer, gastric cancer, and cancers from different ethnicity, and the results should be interpreted with caution.
机译：背景/目的：据报道，Krüppel样因子6干预序列（KLF6 IVS）1-27 G> A可能与癌症易感性有关。在这里，我们进行了荟萃分析以总结和阐明这种关联。材料和方法/主要结果：在数据库中系统搜索了有关KLF6 IVS 1-27 G> A与癌症易感性之间关系的研究。赔率和95％置信区间用于合并效应量。我们的荟萃分析包括七篇文章。总体和前列腺癌，总体人群亚组和白种人亚组，在任何遗传模型中均未发现KLF6 IVS 1-27 G> A多态性与癌症易感性之间的关联，结果表明敏感性分析稳定。结论：KLF6 IVS 1-27 G> A可能与癌症易感性无关，尤其是未选前列腺癌的易感性。但是，没有足够的数据来完全证实KLF6 IVS 1-27 G> A与家族性前列腺癌，散发性前列腺癌，胃癌和不同种族的癌症之间的相关性，应谨慎解释结果。

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