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首页> 外文期刊>Journal of Cancer Research and Treatment >Long Non-Coding RNAs: Novel Emergent Biomarkers for Cancer Diagnostics
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Long Non-Coding RNAs: Novel Emergent Biomarkers for Cancer Diagnostics

机译：长非编码RNA：用于癌症诊断的新型新兴生物标志物

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摘要

Long non-coding RNAs are a novel class of approximately 15,000 – 20,000 non-protein coding RNAs, having a base length of over 200 nucleotides and are the result of RNA Polymerase II activities. Long non-coding RNAs have only just recently been identified to play a major role in gene regulatory pathways for a wide spectrum of human disease conditions, including multiple cancer models. This review article serves to outline, through recent scientific evidence, the emerging importance of long non-coding RNAs as key biomarkers in cancer diagnostics and therapeutics within the clinical setting. Ultimately, there will be soon the establishment of long non-coding RNA expression profile signature analyses on a par level with other molecular diagnostic techniques such as mRNA and miRNA expression profiles for the identification and monitoring of tumour progression and sensitivity to treatment within the individual cancer patient.
机译：长的非编码RNA是一类新的大约15,000 – 20,000的非蛋白质编码RNA，其碱基长度超过200个核苷酸，是RNA聚合酶II活性的结果。直到最近才发现，长的非编码RNA在多种人类疾病（包括多种癌症模型）的基因调控途径中起着重要作用。这篇综述文章旨在通过最新的科学证据概述长非编码RNA作为临床环境中癌症诊断和治疗中关键生物标志物的重要性。最终，很快将建立与其他分子诊断技术（例如mRNA和miRNA表达谱）同等水平的长期非编码RNA表达谱特征分析，以鉴定和监测肿瘤进展以及对单个癌症的治疗敏感性患者。

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