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首页> 外文期刊>Journal of Cancer Research and Treatment >Abrogation by Curcumin on Testicular Toxicity Induced by Cisplatin in Rats
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Abrogation by Curcumin on Testicular Toxicity Induced by Cisplatin in Rats

机译：姜黄素对大鼠顺铂所致睾丸毒性的抑制作用

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Cisplatin is one of the most effective and widely-used antineoplastic agents for the treatment of testicular germ cell tumors. The present study was conducted to examine the possible modifying effects of curcumin against testicular toxicity induced by cisplatin in male rats. 60 male albino rats were equally divided into six groups; the first and second groups were the control and curcumin treated group respectively while the 3rd group was cisplatin treated group; the 4th and 5th groups were co- and post treated cisplatin rat with curcumin respectively and the 6th group was self treated cisplatin rat group. Many side effects were observed in animals injected with cisplatin such as loosing of body weight, loss of activity, weakness, yellowish body hair. A significant decrease in the body and testicular weights,, sperm counts, sperm motility, plasma testosterone, luteinizing hormone reduced glutathione, total antioxidant capacity, and total protein levels in cisplatin and cisplatin self treated groups when compared with the control group. On the other hand; a significant increase in the MDA and NO in cisplatin and cisplatin self treated groups when compared with the control group. sperm count and sperm motility, GSH and TAC exhibited significant increased in cisplatin treated with curcumin when compared with cisplatin groups, moreover, sperm abnormality, MDA, NO and total protein exhibited significant decrease in cisplatin treated groups with curcumin when compared with cisplatin groups. A significant decrease in sperm abnormality, MDA, NO and total protein and a significant increase in GSH and TAC in Co-treated group when compared with post treated cisplatin with curcumin. Our recommendation, administration of curcumin caused ameliorative effect against cisplatin-induced testicular toxicity.
机译：顺铂是用于治疗睾丸生殖细胞肿瘤的最有效和广泛使用的抗肿瘤药之一。进行本研究以检查姜黄素对顺铂对雄性大鼠睾丸毒性的可能修饰作用。将60只雄性白化病大鼠平均分为六组;第一组和第二组分别为对照组和姜黄素治疗组，第三组为顺铂治疗组。第四组和第五组分别为顺铂和姜黄素联合治疗和后治疗，第六组为顺铂大鼠自治疗。在注射顺铂的动物中观察到许多副作用，例如体重减轻，活动丧失，虚弱，体毛发黄。与对照组相比，顺铂和顺铂自治疗组的体重明显下降，精子数量，精子活力，血浆睾丸激素，黄体生成素降低谷胱甘肽，总抗氧化能力和总蛋白水平。另一方面;与对照组相比，顺铂和顺铂自治疗组的MDA和NO显着增加。与顺铂组相比，用姜黄素治疗的顺铂的精子数量和精子活力，GSH和TAC显着增加，此外，与顺铂组相比，用姜黄素治疗的顺铂组的精子异常，MDA，NO和总蛋白均显着降低。与姜黄素顺铂联合治疗组相比，联合治疗组的精子异常，MDA，NO和总蛋白显着降低，GSH和TAC显着增加。我们的建议是，姜黄素的给药可改善顺铂引起的睾丸毒性。

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