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首页> 外文期刊>Journal of Cancer Research and Treatment >Exploration of Cognitive Functioning in a Pilot Sample of Childhood Cancer Patients in Egypt
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Exploration of Cognitive Functioning in a Pilot Sample of Childhood Cancer Patients in Egypt

机译：埃及儿童癌症患者试点认知功能的探索

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A subset of cancer survivors experience cognitive deficits that can last for many years after the completion of chemotherapy. The etiology of this problem is largely unknown, so the present study aimed to assess cognitive functioning in childhood patients with cancer and to investigate the proposed disposing factors including variables related to disease, treatment, and some socio-demographic characteristics. In a case control study parents of 67 cancer patients aged 8-12 years, completed the parent proxy report of PedsQL? 3.0 Cognitive Functioning Scale (Arabic versions), as well as a separate sheet for socio-demographic data. Control group consisted of 37 healthy subjects from the same age group were subjected to the same methodology for comparison. All patients under the study have successfully accomplished their treatment protocol and were in complete remission during the evaluation. Hematological malignancies represented 70.1% of the patients sample, with the highest proportion for ALL (52.2%). Brain tumors represented 40% of the solid malignancies (29.9% of the study patients). Cognitive functioning score was significantly lower in the solid group (69.6±37.3) compared to the hematologic group (85.1±22.2) (t = 2.1, p =0.038). Cognitive functioning score was also lower in solid group versus control subjects (p =0.047), while it showed no significant difference between hematological malignancies and control group. Older age at diagnosis, urban residence, illiterate mothers, higher duration of treatment as well as long duration of hospital admission were associated with a lower cognitive score in the solid tumors group compared to hematological group.
机译：癌症幸存者的一部分经历了认知缺陷，这种缺陷在化学疗法完成后会持续很多年。这个问题的病因学很大程度上是未知的，因此本研究旨在评估儿童期癌症患者的认知功能，并研究提议的治疗因素，包括与疾病，治疗和某些社会人口统计学特征有关的变量。在一项病例对照研究中，对67位8-12岁癌症患者的父母填写了PedsQL？的父母代理报告。 3.0认知功能量表（阿拉伯语版），以及社会人口统计学数据的单独表格。对照组由来自同一年龄段的37名健康受试者组成，他们采用相同的方法进行比较。该研究中的所有患者均已成功完成治疗方案，并且在评估过程中完全缓解。血液学恶性肿瘤占患者样本的70.1％，其中ALL的比例最高（52.2％）。脑肿瘤占实体恶性肿瘤的40％（所研究患者的29.9％）。与血液学组（85.1±22.2）相比，固定组（69.6±37.3）的认知功能评分显着降低（t = 2.1，p = 0.038）。实体组的认知功能评分也比对照组低（p = 0.047），而血液恶性肿瘤与对照组之间无显着差异。与血液学组相比，实体瘤组的诊断年龄，城市居民，文盲母亲，较高的治疗时间以及较长的住院时间与较低的认知评分相关。

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