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首页> 外文期刊>Journal of Cancer Research and Treatment >Expression of Molecular Markers and Risk Categorization in Pre-neoplastic and Non-neoplastic Cervical Lesions
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Expression of Molecular Markers and Risk Categorization in Pre-neoplastic and Non-neoplastic Cervical Lesions

机译：肿瘤前和非肿瘤宫颈病变的分子标志物表达和风险分类

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Worldwide, cervical cancer is the fourth most common cancer in women [1]. It is preceded by many stages of pre-neoplastic lesions classified as Atypical squamous cells of undetermined significance (ASC-US) / Atypical squamous cells cannot exclude HSIL (ASC-H), Low-grade squamous intraepithelial lesion (LSIL), and High-grade squamous intraepithelial lesion (HSIL) (Bethesda, 2001). However, a large proportion of cases of epithelial malignancy arise from apparently normal cell and also from the LSIL where as many HSILs remain static for many years [2]. In this study, many important markers and epidemiological parameters Pap smears were examined to look for high risk cases of cervical non-malignant lesions. Methods: A total of 60 cases and controls were selected by colposcopic examination and smears were collected. Slides were used for immunohistochemical staining for four markers: p53, Ki-67, PCNA and CEA and PAP stain. All experimentally generated data were analyzed by Epi Info (TM) 3.5.3. Results: Expression of PCNA, p53, Ki-67 and CEA were significantly associated with both in Epithelial Cell Abnormalities (ECA) and Negative for Intraepithelial Lesion or Malignancy (NILM). Among HSIL, LSIL and ASCUS, HSIL was more common in Muslim women in comparison to Hindus. Whereas inflammatory lesions like RCC and RCCI were more common in Hindu population. Muslim women have a more normal Cytopathology smear than Hindus. Conclusions: Both the NILM and ECA cases carry risk for cancer conversion. Women with High grade Squamous Intraepithelial lesion or HSIL with PCNA, p53, Ki-67 and CEA strong positivity may have a higher risk of developing cervical cancer.
机译：在世界范围内，子宫颈癌是女性中第四大最常见的癌症[1]。在此之前，有许多阶段的肿瘤前病变被分类为意义不明的非典型鳞状上皮细胞（ASC-US）/非典型鳞状上皮细胞不能排除HSIL（ASC-H），低度鳞状上皮内病变（LSIL）和高级别鳞状上皮内病变（HSIL）（贝塞斯达，2001年）。然而，上皮恶性肿瘤的很大一部分来自明显正常的细胞，也来自LSIL，因为许多HSIL多年来保持静止[2]。在这项研究中，检查了许多重要的标志物和流行病学参数子宫颈抹片检查以寻找宫颈非恶性病变的高危病例。方法：通过阴道镜检查选择60例病例和对照组，并收集涂片。将载玻片用于四个标记的免疫组织化学染色：p53，Ki-67，PCNA和CEA和PAP染色。所有实验产生的数据均通过Epi Info（TM）3.5.3进行了分析。结果：PCNA，p53，Ki-67和CEA的表达与上皮细胞异常（ECA）和上皮内病变或恶性阴性（NILM）均显着相关。在HSIL，LSIL和ASCUS中，与印度教徒相比，HSIL在穆斯林妇女中更为常见。而诸如RCC和RCCI之类的炎性病变在印度教人群中更为常见。穆斯林妇女的细胞病理学涂片比印度教徒更正常。结论：NILM和ECA病例均具有癌症转化的风险。患有高度鳞状上皮内病变或HSIL且PCNA，p53，Ki-67和CEA阳性的女性可能会更容易患宫颈癌。

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