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首页> 外文期刊>Journal of Cancer Research and Treatment >Adipocyte-fatty Acid Binding Protein is Associated with Clinical Stage and Inflammatory Markers in Head and Neck Cancer Patients
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Adipocyte-fatty Acid Binding Protein is Associated with Clinical Stage and Inflammatory Markers in Head and Neck Cancer Patients

机译：脂肪细胞脂肪酸结合蛋白与头颈癌患者的临床分期和炎症标志物相关

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Background: Head and neck carcinomas are the fifth most common cancer worldwide. Squamous cell carcinoma of the head and neck (HNSCC) is a highly heterogeneous tumor. Additional clinical and biological factors are needed to improve tumor diagnosis and to identify subsets of patients with unfavorable outcome. Several recent studies showed that cancer cells stimulate lipid metabolism during tumor progression. Studies have revealed the involvement of fatty acid binding proteins (FABPs) expression in the pathology of different diseases including malignant neoplasms. It has been suggested that the immune changes occurring in the tumour environment determine its aggressive behavior, these changes may affect the prognosis and treatment outcomes in patients with cancer. The tumor necrosis factor (TNF-α) is a proinflammatory cytokine that expressed in HNSCC has a possible role in cancer invasiveness and the risk of metastases. C-reactive protein (C-RP) is an acute-phase protein that increases in acute, chronic inflammations, infections and tissue damages. It has been suggested that C-RP also is elevated in cancers. Objective: The aim of this study was to determine whether the plasma levels of A-FABP are linked to head and neck cancer, inflammatory markers (TNF-α and C-RP) and tumor characteristics. Subjects and Methods: The present study was conducted on 50 healthy individuals and 50 newly diagnosed patients with histologically confirmed HNSCC that accepted to participate. Patients with distant metastases at time of diagnosis, hepatic insufficiency, active autoimmune or coexisting infectious disease were excluded. The study included HNSCC patients with tumours ranged from stage I-IVA (cT1-4a, N0-2, M0). Age, sex, date of diagnosis, tumor site, grade, TNM stage and treatment were recorded. Results: Statistical analysis of the results showed that the mean values of plasma A-FABP, TNF-α and C-RP in HNSCC patients before treatment were significantly higher than that in control group. The plasma levels of the three biomarkers were significantly decreased after treatment than their corresponding values before treatment and plasma C-RP levels became within the normal control values. The risk for head and neck cancer is significantly increased in higher plasma A-FABP group compared with lower levels group. A significant positive correlation was found between plasma A-FABP and both TNF-α and C-RP. There was also a significant correlation observed between plasma A-FABP levels and clinical stage. On the other hand, no correlation was found between plasma levels of TNF-α or C-RP and clinical stage. The three biomarkers were not correlated with other paramters like patient's age, sex, BMI or smoking status. Conclusions: The findings in the present study suggested elevated levels of A-FABP, TNF-α and CRP in HNSCC patients before treatment that significantly decreased after treatment. Higher plasma A-FABP is associated with clinical stage and risk of HNSCC.
机译：背景：头颈癌是全球第五大最常见的癌症。头颈部鳞状细胞癌（HNSCC）是高度异质性肿瘤。还需要其他临床和生物学因素来改善肿瘤诊断并确定预后不良的患者亚群。最近的几项研究表明，癌细胞在肿瘤进展过程中会刺激脂质代谢。研究表明，脂肪酸结合蛋白（FABP）的表达参与了包括恶性肿瘤在内的各种疾病的病理过程。已经提出，在肿瘤环境中发生的免疫变化决定了其侵略行为，这些变化可能影响癌症患者的预后和治疗结果。肿瘤坏死因子（TNF-α）是一种在HNSCC中表达的促炎细胞因子，在癌症侵袭和转移风险中可能发挥作用。 C反应蛋白（C-RP）是一种急性期蛋白，在急性，慢性炎症，感染和组织损伤中会增加。已经提出C-RP在癌症中也升高。目的：本研究的目的是确定血浆A-FABP水平是否与头颈癌，炎症标志物（TNF-α和C-RP）和肿瘤特征有关。受试者和方法：本研究是对50名健康个体和50名接受组织学确认的经组织学确认的HNSCC的新诊断患者进行的。诊断时有远处转移，肝功能不全，主动自身免疫或并存传染病的患者被排除在外。该研究包括HNSCC患者，其肿瘤范围从I-IVA期（cT1-4a，N0-2，M0）。记录年龄，性别，诊断日期，肿瘤部位，等级，TNM分期和治疗。结果：对结果的统计分析表明，治疗前HNSCC患者血浆A-FABP，TNF-α和C-RP的平均值均显着高于对照组。与治疗前相比，治疗后三种生物标志物的血浆水平显着降低，血浆C-RP水平达到正常对照值。血浆A-FABP较高的组与较低水平的组相比，发生头颈癌的风险显着增加。发现血浆A-FABP与TNF-α和C-RP之间存在显着的正相关。血浆A-FABP水平与临床分期之间也存在显着相关性。另一方面，在血浆TNF-α或C-RP水平与临床分期之间未发现相关性。这三种生物标志物与患者年龄，性别，BMI或吸烟状态等其他参数均不相关。结论：本研究发现提示HNSCC患者治疗前A-FABP，TNF-α和CRP水平升高，治疗后明显降低。血浆A-FABP升高与临床分期和HNSCC风险相关。

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