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首页> 外文期刊>Journal of Cancer Research and Treatment >Apoptosis: Insights into Pathways and Role of p53, Bcl-2 and Sphingosine Kinases
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Apoptosis: Insights into Pathways and Role of p53, Bcl-2 and Sphingosine Kinases

机译：凋亡：对p53，Bcl-2和鞘氨醇激酶的途径和作用的见解。

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Apoptosis or programmed cell death is characterized by certain morphological and biochemical characteristics. It is a vital process for normal cell turnover, proper development and functioning of the immune system, embryonic development and chemical-induced cell death. Disturbances of apoptosis play a key role in many diseases including neurodegenerative diseases, autoimmune disorders and many types of cancer. The field of apoptosis research has been moving forward at a rapid rate. Although many of the key proteins that play a role in apoptosis have been identified, the molecular mechanisms of action of these proteins had not been fully elucidated. The aim of this mini-review is to provide a general overview on the process of apoptosis including pathways, regulation, the role of apoptosis in health and disease as well as the role of p53, Bcl-2 and sphingosine kinase-1 in apoptosis.
机译：细胞凋亡或程序性细胞死亡的特征是某些形态和生化特征。对于正常的细胞更新，免疫系统的正常发育和功能，胚胎发育以及化学诱导的细胞死亡，这是至关重要的过程。凋亡的障碍在许多疾病中起关键作用，包括神经退行性疾病，自身免疫性疾病和许多类型的癌症。细胞凋亡研究领域正在迅速发展。尽管已鉴定出许多在细胞凋亡中起作用的关键蛋白，但尚未充分阐明这些蛋白的分子作用机理。本微型综述的目的是提供有关凋亡过程的一般概述，包括途径，调控，凋亡在健康和疾病中的作用以及p53，Bcl-2和鞘氨醇激酶1在凋亡中的作用。

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