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首页> 外文期刊>Journal of Cancer Research and Treatment >Molecular Profiling for Clinical Decision Making in Advanced Cancer: A Clinical Appraisal
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Molecular Profiling for Clinical Decision Making in Advanced Cancer: A Clinical Appraisal

机译：用于晚期癌症临床决策的分子谱分析：临床评估

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In the past five years, technological advances in the field of precision medicine in oncology have led to the emergence of a number of commercially available services for tumor profiling. There is an increased acceptance of these services that can help in finding treatment options based on molecular alterations as individual case reports have shown outstanding response to targeted therapies. Tumor profiling must seek to augment, rather than replace, existing local testing with the objective of helping more patients to find appropriate treatment options. The opportunity has arrived to integrate these services into the clinical setting, specifically in cases of refractory and rare tumors. The promise of precision medicine is clear but conclusive demonstration of how each of the different services delivers on the promise is not uniformly forthcoming. The selection of which service is most appropriate must be based on demonstrated analytical validation, quality standards, and data on clinical benefit and utility. The aims of this paper are to evaluate three tumor tissue profiling services commercially available and to propose to the physician how molecular profiling information can be used in clinical treatment decisions today.
机译：在过去的五年中，肿瘤学上精密医学领域的技术进步导致出现了许多可用于肿瘤分析的商业服务。随着个别病例报告显示出对靶向疗法的出色反应，对这些服务的接受度越来越高，这些服务有助于基于分子改变寻找治疗方案。肿瘤轮廓分析必须寻求增加而不是替代现有的局部检测，以帮助更多的患者找到合适的治疗方案。有机会将这些服务整合到临床环境中的机会已经来临，特别是在难治性和罕见肿瘤的情况下。精准医学的承诺很明确，但是关于每种不同服务如何兑现承诺的结论性展示并不统一。选择哪种服务最合适，必须基于已证明的分析验证，质量标准以及有关临床益处和实用性的数据。本文的目的是评估三种市售的肿瘤组织概况分析服务，并向医生建议如何将分子概况分析信息用于当今的临床治疗决策。

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