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首页> 外文期刊>Journal of Cancer Research and Treatment >Prognostic Factors in Advanced Non-Small Cell Lung Cancer and Their Relation to Clinical Outcomes
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Prognostic Factors in Advanced Non-Small Cell Lung Cancer and Their Relation to Clinical Outcomes

机译：晚期非小细胞肺癌的预后因素及其与临床结局的关系

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Background: Lung cancer is the main cause of cancer deaths worldwide. It is important to identify the prognostic factors of this disease which leads to low survival times despite the advancing treatment modalities. Aim: To investigate the role of clincopathological parameters and treatment modality as a prognostic factors affecting survival of patients with advanced non-small cell lung cancer (NSCLC). Methods: We retrospectively reviewed the clinical records of patients with inoperable stage III/IV NSCLC, who were treated at the department of Clinical Oncology, Assiut University Hospital between 2009 and 2014. The association between the demographic and clinical characteristics and survival of these patients was analyzed. Results: A total of 69 patients (32 stage III& 39 stage IV) were identified and included in this study. Sex (males vs. females, p=0.04), Eastern cooperative Oncology group performance status (0 vs. 1 vs. 2, p=0.001), smoking habit (never vs. current vs. former, p=0.001), stage (IIIA vs. IIIB vs. IV, p=0.008) and the initial treatment (no vs. chemotherapy vs. concurrent chemoradiotherapy, p=0.001) were found to be factors affecting survival in univariate analyses. Sex and histological subtype did not affect survival. Performance status, stage and initial treatment were determined as the independent prognostic factors affecting survival in multivariate analyses. Conclusion: Performance status, stage and initial treatment with concurrent chemoradiotherapy in eligible patients were prognostic factors affecting overall survival of patients with advanced NSCLC.
机译：背景：肺癌是全球癌症死亡的主要原因。重要的是要确定这种疾病的预后因素，尽管治疗方法不断提高，但预后因素却导致生存期缩短。目的：探讨临床病理参数和治疗方式作为影响晚期非小细胞肺癌（NSCLC）患者生存的预后因素。方法：我们回顾性回顾了2009年至2014年间在阿修特大学医院临床肿瘤科接受治疗的III / IV期非手术NSCLC患者的临床记录。这些患者的人口统计学，临床特征与生存率之间的相关性为分析。结果：总共鉴定出69例患者（32例III期和39例IV期）并纳入本研究。性别（男性vs.女性，p = 0.04），东部合作肿瘤小组的表现状态（0 vs. 1 vs. 2，p = 0.001），吸烟习惯（从不与现在和以前相比，p = 0.001），阶段（ IIIA vs. IIIB vs IV，p = 0.008）和初始治疗（无vs.化疗vs.同期放化疗，p = 0.001）是影响单因素分析生存的因素。性别和组织学亚型不影响生存。在多变量分析中，性能状态，阶段和初始治疗被确定为影响生存的独立预后因素。结论：合格患者的治疗状况，阶段和初始治疗以及同步放化疗是影响晚期NSCLC患者总体生存的预后因素。

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