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首页> 外文期刊>Journal of Cardiovascular Disease Research >Is Cardiovascular Risk Associated with Subclinical Hypothyroidism: Role of C Reactive Protein and Interleukin-6
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Is Cardiovascular Risk Associated with Subclinical Hypothyroidism: Role of C Reactive Protein and Interleukin-6

机译：是亚临床甲状腺功能减退症相关的心血管风险：C反应蛋白和白介素6的作用

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Background: Subclinical hypothyroidism causes development of cardiovascular risk is not very well defined due to contradictory findings over the years. Role of inflammatory markers in Subclinical hypothyroidism is not very well studied in the past. Objective: The main objective of this study was to assessment of the role of interleukin-6 and C reactive protein in subclinical hypothyroidism patients having TSH <10μIU/ml. Material and Method: Total 90 young adult males from 20-40 years age group were recruited for the study in which 60 males were with recently diagnosed subclinical hypothyroidism and remaining 30 males were healthy controls. Subclinical hypothyroidism was diagnosed by measuring TSH and FT4, which were estimated by enzyme linked immunosorbent assay (ELISA). Total cholesterol, triglycerides, and High Density Lipoprotein-cholesterol were estimated by spectrophotometric method. Friedewald formula was used for the estimation of Low Density Lipoprotein cholesterol. Lipoprotein ratios (total cholesterol/HDL-cholesterol and LDL-Cholesterol/ HDL-cholesterol) were also estimated. C reactive protein and interleukin-6 were also estimated by ELISA. Results : Significant results were obtained among the various parameters between the groups. Thyroid stimulating hormone was significantly (<0.001) different between patients and control group. In subclinical hypothyroidism patients total cholesterol, triglycerides and LDL cholesterol were significantly higher (<0.01). HDL cholesterol was significantly (<0.001) lower in the patient group. Lipoprotein ratios were also highly significant (<0.001) between the groups and concentrations were higher in the patient group. C reactive protein and interleukin-6 were highly significant (<0.001) between the groups. Conclusion: Subclinical hypothyroidism patients having TSH<10μIU/ml are characterized by the atherogenic lipid profile. Increased concentration of interleukin-6 along with higher concentration of C reactive protein might be the sign of early risk of atherogenic risk progression.
机译：背景：由于多年来的发现矛盾，亚临床甲状腺功能减退症导致心血管风险的发展尚不十分明确。过去，炎症标记物在亚临床甲状腺功能减退症中的作用尚未得到很好的研究。目的：本研究的主要目的是评估白细胞介素6和C反应蛋白在TSH <10μIU/ ml的亚临床甲状腺功能减退症患者中的作用。材料和方法：招募了来自20-40岁年龄组的90位年轻成年男性进行研究，其中60位男性最近被诊断出亚临床甲状腺功能减退，其余30位男性为健康对照。亚临床甲状腺功能减退症是通过测量TSH和FT4来诊断的，TSH和FT4是通过酶联免疫吸附测定（ELISA）估算的。通过分光光度法估算总胆固醇，甘油三酸酯和高密度脂蛋白胆固醇。 Friedewald公式用于估计低密度脂蛋白胆固醇。还估计了脂蛋白比率（总胆固醇/ HDL-胆固醇和LDL-胆固醇/ HDL-胆固醇）。还通过ELISA估计了C反应蛋白和白介素-6。结果：在各组之间的各个参数之间获得了显着的结果。患者与对照组之间的促甲状腺激素差异显着（<0.001）。在亚临床甲状腺功能减退症患者中，总胆固醇，甘油三酸酯和低密度脂蛋白胆固醇明显升高（<0.01）。在患者组中，HDL胆固醇显着降低（<0.001）。脂蛋白比率在各组之间也非常显着（<0.001），并且患者组中的浓度更高。两组之间的C反应蛋白和白介素6高度显着（<0.001）。结论：TSH <10μIU/ ml的亚临床甲状腺功能减退症患者具有动脉粥样硬化性脂质特征。白细胞介素6浓度增加以及C反应蛋白浓度升高可能是动脉粥样硬化风险进展的早期风险的征兆。

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