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首页> 外文期刊>Journal of Cancer Research and Therapeutics >MicroRNA-146a rs2910164 G/C polymorphism and gastrointestinal cancer susceptibility: A meta-analysis based on East Asian population
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MicroRNA-146a rs2910164 G/C polymorphism and gastrointestinal cancer susceptibility: A meta-analysis based on East Asian population

机译：MicroRNA-146a rs2910164 G / C基因多态性与胃肠道癌的易感性：基于东亚人群的荟萃分析

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Objective: The relationship between microRNA (miR-146a) rs2910164G/C polymorphism and gastrointestinal cancer susceptibility is not consistent with each other of the published articles. The aim of this meta-analysis was to acquire a more precise effect of the association between the miR-146a rs2910164 G/C polymorphism and gastrointestinal cancer. Materials and Methods: Through searching of the MedLine, Embase, China National Knowledge Infrastructure, and Wanfang databases. Case-control or cohort studies about the relationship between miR-146a rs2910164 G/C polymorphism and gastrointestinal cancer susceptibility were screened and included in this meta-analysis. Quantitative data synthesis was conducted for the associations of miR-146a rs2910164 G/C polymorphism and gastrointestinal cancer risk by statistical software STATA-11.0. Results: Ten studies including 6473 gastrointestinal cancer patients and 7923 controls were identified and included in this meta-analysis. For recessive genetic model (CC vs. CG + GG), people with CG or GG is associated with the susceptibility of gastrointestinal cancer compared with genotype of CC (R = 0.73, 5% confidence interval [CI]: 0.55-0.97, [P = 0.03]); But for dominant model (CC + CG vs. GG) and homozygous model (CC vs. GG), no association of the miR-146a rs2910164G/C polymorphism and gastrointestinal cancer susceptibility were found (dominant: Odds ratio [OR] =0.94, 95% CI: 0.82-1.03, [P = 0.37]; homozygous: OR = 0.85, 95% CI: 0.71-1.03, [P = 0.10]). Sub-group analysis, for homozygous model, people with GG genotype had increased risk of developing colorectal cancer (OR = 0.77, 95% CI: 0.64-0.93, [P = 0.008]). Conclusion: No significant association between miR-146a rs2910164G/C polymorphism and gastrointestinal cancer susceptibility was found in this meta-analysis. But for homozygous model, people with GG genotype may have increased risk of developing colorectal cancer.
机译：目的：microRNA（miR-146a）rs2910164G / C多态性与胃肠道癌易感性之间的关系彼此不一致。这项荟萃分析的目的是获得miR-146a rs2910164 G / C多态性与胃肠道癌之间关联的更精确效果。材料和方法：通过搜索MedLine，Embase，中国国家知识基础设施和Wanfang数据库。筛选了关于miR-146a rs2910164 G / C多态性与胃肠道癌易感性之间关系的病例对照研究或队列研究，并将其纳入该荟萃分析。通过统计软件STATA-11.0对miR-146a rs2910164 G / C多态性与胃肠道癌症风险之间的关系进行了定量数据综合。结果：确定了10项研究，包括6473例胃肠道癌症患者和7923例对照，并将其纳入本荟萃分析。对于隐性遗传模型（CC vs. CG + GG），与CC基因型相比，患有CG或GG的人与胃肠道癌的易感性相关（R = 0.73，5％置信区间[CI]：0.55-0.97，[P = 0.03]）;但对于优势模型（CC + CG与GG）和纯合模型（CC与GG），未发现miR-146a rs2910164G / C多态性与胃肠道癌易感性相关（优势：比值比[OR] = 0.94， 95％CI：0.82-1.03，[P = 0.37];纯合：OR = 0.85，95％CI：0.71-1.03，[P = 0.10]）。亚组分析，对于纯合子模型，具有GG基因型的人发生结直肠癌的风险增加（OR = 0.77，95％CI：0.64-0.93，[P = 0.008]）。结论：该荟萃分析未发现miR-146a rs2910164G / C多态性与胃肠道癌易感性之间存在显着关联。但是对于纯合子模型，GG基因型的人患结直肠癌的风险可能会增加。

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