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首页> 外文期刊>Journal of Cancer Research and Therapeutics >Vemurafenib-related sterile scrotal abscess in a patient with BRAFV600K-mutant advanced melanoma mimicking distant metastasis
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Vemurafenib-related sterile scrotal abscess in a patient with BRAFV600K-mutant advanced melanoma mimicking distant metastasis

机译：维拉非尼相关的无菌阴囊脓肿伴BRAFV600K突变的晚期转移性黑色素瘤模仿远处转移

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Background: Vemurafenib is a selective BRAF-inhibitor that has been approved for the use in patients with advanced BRAF-mutant melanoma. Major adverse events include skin rash, photosensitivity, pruritus, cutaneous squamous-cell carcinoma or keratoacanthoma. Observation: We present the case of a patient experiencing extensive sterile abscess of the scrotum after nine months of treatment with vemurafenib for oligometastatic (liver) BRAF-mutant melanoma. The scrotal lesion mimicked distant metastasis in a first round of clinical and radiological examinations, but was identified as sterile abscess after surgical exploration and complete excision. The patient went on to receive hemihepatectomy for melanoma supposedly confined to the liver, and continues receiving vemurafenib. Conclusions: We describe a remarkable case of probably vemurafenib-related sterile abscess. This adverse event is of substantial clinical relevance, as it mimicks metastatic melanoma and requires careful diagnostic evaluation and proper treatment to allow a favorable patient outcome.
机译：背景：Vemurafenib是一种选择性的BRAF抑制剂，已被批准用于晚期BRAF突变型黑色素瘤患者。主要不良事件包括皮疹，光敏性，瘙痒，皮肤鳞状细胞癌或角棘皮瘤。观察：我们介绍了一名患者在接受vemurafenib治疗少转移（肝）BRAF突变型黑色素瘤治疗九个月后出现阴囊广泛无菌脓肿的病例。在第一轮临床和放射学检查中，阴囊病灶模仿了远处转移，但经外科手术探查和完全切除后被确认为无菌脓肿。患者继续接受据称局限于肝脏的黑色素瘤半肝切除术，并继续接受维罗非尼治疗。结论：我们描述了与维拉非尼相关的无菌性脓肿的显着病例。该不良事件与转移性黑色素瘤相似，因此具有重大的临床意义，需要仔细的诊断评估和适当的治疗，才能使患者获得良好的治疗效果。

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