Probing the Electrophysiology of the Developing Heart

Michiko Watanabe; Andrew M. Rollins; Luis Polo-Parada; Pei Ma; Shi Gu; Michael W. Jenkins

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Probing the Electrophysiology of the Developing Heart

机译：探索心脏发育的电生理

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Many diseases that result in dysfunction and dysmorphology of the heart originate in the embryo. However, the embryonic heart presents a challenging subject for study: especially challenging is its electrophysiology. Electrophysiological maturation of the embryonic heart without disturbing its physiological function requires the creation and deployment of novel technologies along with the use of classical techniques on a range of animal models. Each tool has its strengths and limitations and has contributed to making key discoveries to expand our understanding of cardiac development. Further progress in understanding the mechanisms that regulate the normal and abnormal development of the electrophysiology of the heart requires integration of this functional information with the more extensively elucidated structural and molecular changes.

机译：导致心脏功能障碍和畸形的许多疾病都起源于胚胎。然而，胚胎心脏提出了一个具有挑战性的研究课题：特别是具有挑战性的是其电生理学。胚胎心脏的电生理成熟而又不影响其生理功能，就需要在一系列动物模型上创造和部署新技术，并运用经典技术。每种工具都有其优势和局限性，并有助于做出重要发现，以扩大我们对心脏发育的了解。在理解调节心脏电生理的正常和异常发展的机制方面的进一步进步要求将这种功能信息与更广泛阐明的结构和分子变化相结合。

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《Journal of Cardiovascular Development and Disease》 |2016年第1期|共页
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Michiko Watanabe; Andrew M. Rollins; Luis Polo-Parada; Pei Ma; Shi Gu; Michael W. Jenkins;
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1. PACES/HRS expert consensus statement on the use of catheter ablation in children and patients with congenital heart disease Developed in partnership with the Pediatric and Congenital Electrophysiology Society (PACES) and the Heart Rhythm Society (HRS). Endorsed by the governing bodies of PACES, HRS, the American Academy of Pediatrics (AAP), the American Heart Association (AHA), and the Association for European Pediatric and Congenital Cardiology (AEPC) [J] . Saul J. Philip, Kanter Ronald J., Abrams Dominic, Heart rhythm: the official journal of the Heart Rhythm Society . 2016,第6期

机译：PACES / HRS关于在儿童和先天性心脏病患者中使用导管消融的专家共识声明是与儿科和先天性电生理学会（PACES）和心律协会（HRS）合作开发的。由PACES，HRS，美国小儿科学院（AAP），美国心脏协会（AHA）和欧洲小儿及先天性心脏病协会（AEPC）的理事机构批准
2. Developing a novel comprehensive framework for the investigation of cellular and whole heart electrophysiology in the in situ human heart: Historical perspectives, current progress and future prospects [J] . Taggart Peter, Orini Michele, Hanson Ben, Progress in Biophysics and Molecular Biology: An International Review Journal . 2014,第2a3期

机译：为研究原位人心脏中的细胞和整个心脏电生理学开发一个新颖的综合框架：历史观点，当前进展和未来前景
3. PACES/HRS Expert Consensus Statement on the Management of the Asymptomatic Young Patient with a Wolff-Parkinson-White (WPW, Ventricular Preexcitation) Electrocardiographic Pattern: Developed in partnership between the Pediatric and Congenital Electrophysiology Society (PACES) and the Heart Rhythm Society (HRS). [J] . CohenM.I., TriedmanJ.K., CannonB.C., Heart rhythm: the official journal of the Heart Rhythm Society . 2012,第6期

机译：PACES / HRS关于Wolff-Parkinson-White（WPW，心室预激）无症状年轻患者管理的心电图专家共识声明：由儿科和先天性电生理学会（PACES）与心律协会（HRS）合作开发）。
4. EP Challenge - STACOM'11: Forward Approaches to Computational Electrophysiology Using MRI-Based Models and In-Vivo CARTO Mapping in Swine Hearts [C] . Mihaela Pop, Maxime Sermesant, Tommaso Mansi, Statistical atlases and computational models of the heart: imaging and modelling challenges. . 2011

机译：EP挑战-STACOM'11：在猪心脏中使用基于MRI的模型和活体CARTO映射进行计算电生理学的正向方法
5. Noninvasive Multi-Modality Studies of Cardiac Electrophysiology, Mechanics, and Anatomical Substrate in Healthy Adults, Arrhythmogenic Cardiomyopathy, and Heart Failure [D] . Andrews, Christopher 2018

机译：健康成年人的心脏电生理，力学和解剖学基质，心律失常性心肌病和心力衰竭的无创多模式研究
6. Probing the Electrophysiology of the Developing Heart [O] . Michiko Watanabe, Andrew M. Rollins, Luis Polo-Parada, 2016

机译：探索心脏发育的电生理
7. ACC/AHA/ESC guidelines for the management of patients with atrial fibrillation31This document was approved by the American College of Cardiology Board of Trustees in August 2001, the American Heart Association Science Advisory and Coordinating Committee in August 2001, and the European Society of Cardiology Board and Committee for Practice Guidelines and Policy Conferences in August 2001.32When citing this document, the American College of Cardiology, the American Heart Association, and the European Society of Cardiology would appreciate the following citation format: Fuster V, Rydén LE, Asinger RW, Cannom DS, Crijns HJ, Frye RL, Halperin JL, Kay GN, Klein WW, Lévy S, McNamara RL, Prystowsky EN, Wann LS, Wyse DG. ACC/AHA/ESC guidelines for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines and Policy Conferences (Committee to Develop Guidelines for the Management of Patients With Atrial Fibrillation). J Am Coll Cardiol 2001;38:XX-XX.33This document is available on the World Wide Web sites of the American College of Cardiology (www.acc.org), the American Heart Association (www.americanheart.org), the European Society of Cardiology (www.escardio.org), and the North American Society of Pacing and Electrophysiology (www.naspe.org). Single reprints of this document (the complete Guidelines) to be published in the mid-October issue of the European Heart Journal are available by calling +44.207.424.4200 or +44.207.424.4389, faxing +44.207.424.4433, or writing Harcourt Publishers Ltd, European Heart Journal, ESC Guidelines – Reprints, 32 Jamestown Road, London, NW1 7BY, United Kingdom. Single reprints of the shorter version (Executive Summary and Summary of Recommendations) published in the October issue of the Journal of the American College of Cardiology and the October issue of Circulation, are available for $5.00 each by calling 800-253-4636 (US only) or by writing the Resource Center, American College of Cardiology, 9111 Old Georgetown Road, Bethesda, Maryland 20814. To purchase bulk reprints specify version and reprint number (Executive Summary 71-0208; full text 71-0209) up to 999 copies, call 800-611-6083 (US only) or fax 413-665-2671; 1000 or more copies, call 214-706-1466, fax 214-691-6342; or E-mail: pubauth@heart.org. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines and Policy Conferences (Committee to Develop Guidelines for the Management of Patients With Atrial Fibrillation) Developed in Collaboration With the North American Society of Pacing and Electrophysiology [O] . Fuster Valentin, Rydén Lars E., Asinger Richard W., 2001

机译：ACC / AHA / ESC治疗房颤患者指南31该文件于2001年8月获得美国心脏病学会董事会，2001年8月美国心脏协会科学咨询与协调委员会以及欧洲心脏病学会的批准以及实践指南和政策委员会会议（2001年8月）。32引用本文件时，美国心脏病学会，美国心脏协会和欧洲心脏病学会将赞赏以下引用格式：Fuster V，RydénLE，Asinger RW，Cannom DS，Crijns HJ，Frye RL，Halperin JL，Kay GN，Klein WW，LévyS，McNamara RL，Prystowsky EN，Wann LS，Wyse DG。 ACC / AHA / ESC治疗房颤患者的指南：美国心脏病学会/美国心脏协会实践指南工作组和欧洲心脏病学会实践指南委员会和政策会议的报告（制定指南委员会）用于房颤患者的治疗）。 J Am Coll Cardiol 2001; 38：XX-XX.33本文件可在美国心脏病学会（www.acc.org），美国心脏协会（www.americanheart.org），欧洲的万维网站点上找到心脏病学会（www.escardio.org）和北美起搏和电生理学会（www.naspe.org）。可致电+44.207.424.4200或+44.207.424.4389，传真+44.207.424.4433或写信给Harcourt Publishers，以获取本文档（完整的准则）的单份重印本（完整的准则），该印刷本将于10月中旬出版。欧洲心脏杂志，ESC指南–转载，英国伦敦詹姆斯敦路32号，NW1 7BY。短版（执行摘要和建议摘要）的单版重印在《美国心脏病学会杂志》十月刊和《循环》十月刊上，致电800-253-4636（仅美国），每本售价5.00美元。）或写信给美国心脏病学院资源中心，地址是：马里兰州贝塞斯达市Old Georgetown Road 9111，邮编20814。要购买批量转载，请指定版本和转载编号（执行摘要71-0208；全文71-0209），最多999份，致电800-611-6083（仅限美国）或传真413-665-2671； 1000或更多副本，请致电214-706-1466，传真214-691-6342;或电子邮件：pubauth@heart.org。美国心脏病学会/美国心脏协会实践指南工作组和欧洲心脏病学会实践指南和政策会议（制定房颤患者治疗指南委员会）的报告是与北方合作开发的美国起搏与电生理学会

Probing the Electrophysiology of the Developing Heart

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