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首页> 外文期刊>Journal of Clinical Medicine Research >Skeletal Malocclusion: A Developmental Disorder With a Life-Long Morbidity
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Skeletal Malocclusion: A Developmental Disorder With a Life-Long Morbidity

机译：骨骼错合：具有终身病的发展障碍

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The likelihood of birth defects in orofacial tissues is high due to the structural and developmental complexity of the face and the susceptibility to intrinsic and extrinsic perturbations. Skeletal malocclusion is caused by the distortion of the proper mandibular and/or maxillary growth during fetal development. Patients with skeletal malocclusion may suffer from dental deformities, bruxism, teeth crowding, trismus, mastication difficulties, breathing obstruction and digestion disturbance if the problem is left untreated. In this review, we focused on skeletal malocclusion that affects 27.9% of the US population with different severity levels. We summarized the prevalence of class I, II and III of malocclusion in different ethnic groups and discussed the most frequent medical disorders associated with skeletal malocclusion. Dental anomalies that lead to malocclusion such as tooth agenesis, crowding, missing teeth and abnormal tooth size are not addressed in this review. We propose a modified version of malocclusion classification for research purposes to exhibit a clear distinction between skeletal vs. dental malocclusion in comparison to Angle’s classification. In addition, we performed a cross-sectional analysis on orthodontic (malocclusion) data through the BigMouth Dental Data Repository to calculate potential association between malocclusion with other medical conditions. In conclusion, this review emphasizes the need to identify genetic and environmental factors that cause or contribute risk to skeletal malocclusion and the possible association with other medical conditions to improve assessment, prognosis and therapeutic approaches.J Clin Med Res. 2014;6(6):399-408doi: http://dx.doi.org/10.14740/jocmr1905w
机译：由于面部的结构和发育复杂性以及对内在和外在扰动的敏感性，口腔组织中出生缺陷的可能性很高。骨骼发育不良是由于胎儿发育过程中正常的下颌和/或上颌骨生长畸变引起的。如果不及时治疗，患有骨骼错合的患者可能患有牙齿畸形，磨牙症，牙齿拥挤，三头肌，咀嚼困难，呼吸阻塞和消化不良。在本文中，我们重点研究了影响严重程度不同的27.9％的美国人群的骨骼错合。我们总结了不同种族人群中I，II和III类错牙合的患病率，并讨论了与骨骼错牙合有关的最常见医学疾病。本评价未解决导致牙合不良的牙齿异常，例如牙齿发育不良，拥挤，牙齿缺失和牙齿大小异常。为了研究的目的，我们提出了错牙合畸形分类的改进版本，以显示与Angle的分类相比骨骼错牙合与牙齿错牙合明显的区别。此外，我们通过BigMouth牙科数据存储库对正畸（咬合不良）数据进行了横断面分析，以计算错牙合畸形与其他医学状况之间的潜在关联。总而言之，本综述强调需要确定引起骨骼错位或对骨骼错位造成风险的遗传和环境因素，以及与其他医学状况可能的关联以改善评估，预后和治疗方法.J Clin Med Res。 2014; 6（6）：399-408doi：http://dx.doi.org/10.14740/jocmr1905w

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