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Importance of Pre-Transplant Colonoscopy in Renal Transplant Recipients

机译:肾移植接受者移植前结肠镜检查的重要性

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Background: Current recommendations for colorectal cancer screening for kidney transplant candidates are the same as for the general population. However, few studies have established the prevalence and characteristics of colorectal polyps in this population. The aim of this study is to describe the prevalence and characteristics of colonic lesions detected by pre-transplant colonoscopies in our kidney transplant population. Methods: A retrospective study was conducted from January 2007 to December 2009 at the Centre Hospitalier de l’Universite de Montreal (Canada). Inclusion criteria are all renal transplant recipients with a test for colorectal cancer screening in the 5 years preceding the transplantation. Patients benefiting of a second transplantation were excluded. The files were reviewed for clinical data, including colonoscopy indication, endoscopic and pathologic results. Advanced lesions were defined as adenomas of 10 mm or greater or with a villous component. Polyps were considered proximal if they were at the level of or above the splenic angle. Results: This study includes 159 patients. A pre-transplant colonoscopy was performed in 40% (n = 64). Polyps were present in 32.8% (n = 21) of colonoscopies and 66.7% of them showed adenomas. Advanced lesions were present in 6.25% of the exams. Finally, 66.7% of patients with polyps had at least one proximal lesion. Conclusions: The prevalence of colorectal polyps before transplant is high among renal transplant recipients. The high prevalence of proximal lesions supports the need for total colonoscopy.J Clin Med Res. 2014;6(6):414-421doi: http://dx.doi.org/10.14740/jocmr1934w
机译:背景:目前针对肾移植候选对象进行大肠癌筛查的建议与普通人群相同。然而,很少有研究确定该人群中结肠直肠息肉的患病率和特征。这项研究的目的是描述在我们的肾脏移植人群中通过移植前结肠镜检查发现的结肠病变的患病率和特征。方法:回顾性研究于2007年1月至2009年12月在加拿大蒙特利尔大学医院中心进行。入选标准为所有肾移植受者,均需在移植前5年进行大肠癌筛查。排除了受益于第二次移植的患者。审查文件的临床数据,包括结肠镜检查适应症,内窥镜检查和病理结果。晚期病变定义为10 mm或更大或有绒毛成分的腺瘤。如果息肉处于脾角水平或以上,则认为息肉近端。结果:这项研究包括159例患者。移植前结肠镜检查占40%(n = 64)。结肠镜检查中有32.8%(n = 21)出现息肉,其中66.7%表现为腺瘤。 6.25%的检查存在晚期病变。最后,有66.7%的息肉患者至少有一个近端病变。结论:肾移植受者中大肠息肉的发生率较高。近端病变的高患病率支持全结肠镜检查。JClin Med Res。 2014; 6(6):414-421doi:http://dx.doi.org/10.14740/jocmr1934w

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