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首页> 外文期刊>Journal of Clinical Medicine >Wound Healing: In Vitro and In Vivo Evaluation of a Bio-Functionalized Scaffold Based on Hyaluronic Acid and Platelet-Rich Plasma in Chronic Ulcers
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Wound Healing: In Vitro and In Vivo Evaluation of a Bio-Functionalized Scaffold Based on Hyaluronic Acid and Platelet-Rich Plasma in Chronic Ulcers

机译：伤口愈合：基于透明质酸和富含血小板血浆的慢性溃疡生物功能支架的体外和体内评价

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Chronic ulcers are characterized by loss of substance without a normal tendency towards spontaneous healing. The Wound Bed Preparation Guideline advises that after diagnosis, the expert should correct the biological state of the ulcer micro-environment based on TIME principles (Tissue, Infection, Moisture balance, Epidermal). There are many ways to treat such ulcers, for example through use of advanced dressings, negative pressure, surgical toilets, dermal substitutes, autologous skin grafting, and free or local flaps. In vitro and in vivo pre-clinical models hold widely acknowledged potential yet complex limitations. Tissue bioengineering could be an ideal approach to foster innovative strategies in wound healing. Our observational study reports on an in vitro and in vivo evaluation of a bio-functionalized scaffold composed of platelet-rich plasma (PRP) and hyaluronic acid (HA) used in 182 patients affected by chronic ulcers (diabetic and vascular), comparing the results with a control group of 182 patients treated with traditional dressings (HA alone). After 30 days the patients who had undergone the combined treatment (PRP + HA), showed 96.8% ± 1.5% re-epithelialization, as compared to 78.4% ± 4.4% in the control group (HA only). Within 80 days, they had 98.4% ± 1.3% re-epithelialization as compared to 87.8% ± 4.1% in the control group (HA only; p 0.05). No local recurrence was observed during the follow-up period. PRP + HA treatment showed stronger regenerative potential in terms of epidermal proliferation and dermal renewal compared with HA alone.
机译：慢性溃疡的特征是物质损失，没有正常的自发愈合趋势。伤口床准备指南建议，诊断后，专家应根据TIME原则（组织，感染，水分平衡，表皮）纠正溃疡微环境的生物学状态。有许多治疗此类溃疡的方法，例如，通过使用高级敷料，负压，外科洗手间，皮肤替代品，自体皮肤移植以及游离或局部皮瓣。体外和体内临床前模型具有公认的潜在但复杂的局限性。组织生物工程可能是在伤口愈合中促进创新策略的理想方法。我们的观察性研究报告了对182名患有慢性溃疡（糖尿病和血管性溃疡）的患者使用的由富含血小板的血浆（PRP）和透明质酸（HA）组成的生物功能化支架的体外和体内评估。对照组为182例接受传统敷料（仅HA）治疗的患者。 30天后，接受联合治疗（PRP + HA）的患者表现出96.8％±1.5％的上皮再形成，而对照组（仅HA）则为78.4％±4.4％。在80天内，他们的上皮再形成率为98.4％±1.3％，而对照组为87.8％±4.1％（仅HA; p <0.05）。在随访期间未观察到局部复发。与单独使用HA相比，PRP + HA处理在表皮增殖和真皮更新方面显示出更强的再生潜力。

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