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首页> 外文期刊>Journal of Clinical Medicine >The Anti-Inflammatory Effects of Fermented Herbal Roots of Asparagus cochinchinensis in an Ovalbumin-Induced Asthma Model
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The Anti-Inflammatory Effects of Fermented Herbal Roots of Asparagus cochinchinensis in an Ovalbumin-Induced Asthma Model

机译：卵清蛋白诱导的哮喘模型中芦笋发酵的中草药根的抗炎作用

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Introduction: Roots of Asparagus cochinchinensis , which have pharmacologically active ingredients, have received great attention because they show good therapeutic effects for various inflammatory diseases without specific toxicity. This study investigated the anti-asthmatic effects of a butanol extract of Asparagus cochinchinensis roots that had been fermented with Weissella cibaria (BAW) and its possible underlying cholinergic regulation. Methods: Alterations of the anti-asthmatic markers and the molecular response factors were measured in an ovalbumin (OVA)-induced asthma model after treatment with BAW. Results: Treatment with BAW decreased the intracellular reactive oxygen species (ROS) production in lipopolysaccharides (LPS) activated RAW264.7 cells. The results of the animal experiments revealed lower infiltration of inflammatory cells and bronchial thickness, and a significant reduction in the number of macrophages and eosinophils, concentration of OVA-specific IgE, and expression of Th2 cytokines in the OVA + BAW treated group. In addition, a significant recovery of goblet cell hyperplasia, MMP-9 expression, and the VEGF signaling pathway was observed upon airway remodeling in the OVA + BAW treated group. Furthermore, these responses of BAW were linked to recovery of acetylcholine esterase (AChE) activity and muscarinic acetylcholine receptor (mAChR) M3 downstream signaling pathway in epithelial cells, smooth muscle cells, and afferent sensory nerves of OVA + BAW-treated mice. Conclusion: Overall, these findings are the first to provide evidence that the therapeutic effects of BAW can prevent airway inflammation and remodeling through the recovery of cholinergic regulation in structural cells and inflammatory cells of the chronic asthma model.
机译：简介：芦笋的根具有药理活性成分，由于它们对各种炎性疾病显示出良好的治疗效果而没有特定的毒性，因此备受关注。这项研究调查了Weissella cibaria（BAW）发酵的天冬芦笋根的丁醇提取物的抗哮喘作用及其可能的胆碱能调节作用。方法：在BAW治疗后，在卵清蛋白（OVA）诱导的哮喘模型中测量抗哮喘标志物和分子反应因子的变化。结果：BAW处理降低了脂多糖（LPS）激活的RAW264.7细胞的细胞内活性氧（ROS）产生。动物实验的结果表明，OVA + BAW治疗组的炎症细胞浸润和支气管厚度降低，巨噬细胞和嗜酸性粒细胞数量减少，OVA特异性IgE浓度降低，Th2细胞因子表达降低。此外，OVA + BAW治疗组在气道重塑后观察到杯状细胞增生，MMP-9表达和VEGF信号通路显着恢复。此外，BAW的这些反应与OVA + BAW处理的小鼠的上皮细胞，平滑肌细胞和传入感觉神经中乙酰胆碱酯酶（AChE）活性和毒蕈碱乙酰胆碱受体（mAChR）M3下游信号通路的恢复有关。结论：总的来说，这些发现是第一个提供证据，证明BAW的治疗作用可以通过恢复慢性哮喘模型的结构细胞和炎症细胞中的胆碱能调节来预防气道炎症和重塑。

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