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首页> 外文期刊>Journal of Clinical Medicine Research >Comparison of Plasma Glucose and Gut Hormone Levels Between Drinking Enteral Formula Over a Period of 5 and 20 Minutes in Japanese Patients With Type 2 Diabetes: A Pilot Study
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Comparison of Plasma Glucose and Gut Hormone Levels Between Drinking Enteral Formula Over a Period of 5 and 20 Minutes in Japanese Patients With Type 2 Diabetes: A Pilot Study

机译：在日本2型糖尿病患者中，在5和20分钟内比较肠内配方食品之间的血浆葡萄糖和肠道激素水平的比较：一项初步研究

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Background: A fast eating speed is reportedly associated with obesity, fatty liver, and metabolic syndrome. As a comparison of postprandial glucose levels after eating quickly or slowly has not been previously reported for Japanese patients with type 2 diabetes, we evaluated the impact of the fast or slow ingestion of an enteral formula (liquid meal) on glucose metabolism.Methods: Ten Japanese patients with type 2 diabetes who had been hospitalized at our hospital were enrolled. All the subjects received an enteral formula for breakfast. The study was performed over a 2-day period in each subject (day 1: enteral formula was consumed over a 5-minute period; day 2: enteral formula was consumed over a 20-minute period). The subjects were requested to fast for at least 12 hours before eating breakfast, and blood samples were collected at 0, 30, 60, and 120 min after the start of breakfast.Results: The areas under the curve (AUCs) of the plasma glucose, serum insulin, plasma active ghrelin, glucagon-like peptide-1 (GLP-1), plasma total glucose-dependent insulinotropic polypeptide (GIP), and serum total peptide YY (PYY) levels were not significantly changed by intake over a 5-minute or 20-minute period.Conclusions: Eating quickly?per se probably does not affect postprandial glucose excursions, but the increased energy intake resulting from eating quickly may increase the body weight and increase insulin resistance. Eating quickly may increase energy intake and worsen long-term metabolic parameters.J Clin Med Res. 2016;8(10):749-752doi: http://dx.doi.org/10.14740/jocmr2686w
机译：背景：据报道，进食速度过快与肥胖，脂肪肝和代谢综合征有关。由于以前没有关于日本2型糖尿病患者进食后快速或缓慢进餐后血糖水平的比较的报道，我们评估了快速或缓慢摄入肠溶配方食品（流质餐）对葡萄糖代谢的影响。方法：十招募了在我院住院的日本2型糖尿病患者。所有受试者都获得了早餐的肠内配方。在每个受试者中进行了为期2天的研究（第1天：在5分钟内消耗了肠溶配方食品;第2天：在20分钟内消耗了肠溶配方食品）。要求受试者在早餐前禁食至少12小时，并在早餐开始后0、30、60和120分钟采集血液样本。结果：血浆葡萄糖的曲线下面积（AUC） ，5-摄入量对血清胰岛素，血浆活动型生长激素释放肽，胰高血糖素样肽1（GLP-1），血浆总葡萄糖依赖性促胰岛素多肽（GIP）和血清总肽YY（PYY）的水平没有显着影响。结论：快速进食本身可能不会影响餐后血糖波动，但快速进食导致的能量摄入增加可能会增加体重并增加胰岛素抵抗。快吃可能会增加能量摄入并恶化长期代谢参数。JClin Med Res。 2016; 8（10）：749-752doi：http://dx.doi.org/10.14740/jocmr2686w

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