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首页> 外文期刊>Journal of Clinical Medicine >The Importance of Time to Prostate-Specific Antigen (PSA) Nadir after Primary Androgen Deprivation Therapy in Hormone-Na?ve Prostate Cancer Patients
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The Importance of Time to Prostate-Specific Antigen (PSA) Nadir after Primary Androgen Deprivation Therapy in Hormone-Na?ve Prostate Cancer Patients

机译：激素初治前列腺癌患者初次雄激素剥夺治疗后到前列腺特异性抗原（PSA）最低点的时间的重要性

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摘要

Prostate-specific antigen (PSA) is currently the most useful biomarker for detection of prostate cancer (PCa). The ability to measure serum PSA levels has affected all aspects of PCa management over the past two decades. The standard initial systemic therapy for advanced PCa is androgen-deprivation therapy (ADT). Although PCa patients with metastatic disease initially respond well to ADT, they often progress to castration-resistant prostate cancer (CRPC), which has a high mortality rate. We have demonstrated that time to PSA nadir (TTN) after primary ADT is an important early predictor of overall survival and progression-free survival for advanced PCa patients. In in vivo experiments, we demonstrated that the presence of fibroblasts in the PCa tumor microenvironment can prolong the period for serum PSA decline after ADT, and enhance the efficacy of ADT. Clarification of the mechanisms that affect TTN after ADT could be useful to guide selection of optimal PCa treatment strategies. In this review, we discuss recent in vitro and in vivo findings concerning the involvement of stromal–epithelial interactions in the biological mechanism of TTN after ADT to support the novel concept of “tumor regulating fibroblasts”.
机译：前列腺特异性抗原（PSA）目前是检测前列腺癌（PCa）最有用的生物标志物。在过去的二十年中，测量血清PSA水平的能力已影响PCa管理的各个方面。晚期PCa的标准初始全身疗法是雄激素剥夺疗法（ADT）。尽管PCa转移性疾病患者最初对ADT的反应良好，但他们通常会发展为去势抵抗性前列腺癌（CRPC），其死亡率很高。我们已经证明，初次ADT后到达PSA最低点（TTN）的时间是晚期PCa患者总体生存和无进展生存的重要早期预测指标。在体内实验中，我们证明了PCa肿瘤微环境中成纤维细胞的存在可以延长ADT后血清PSA下降的时间，并增强ADT的疗效。明确ADT后影响TTN的机制可能有助于指导最佳PCa治疗策略的选择。在这篇综述中，我们讨论了最近的体外和体内发现，这些发现涉及ADT后基质-上皮相互作用参与TTN的生物学机制，以支持“肿瘤调节成纤维细胞”这一新概念。

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