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首页> 外文期刊>Journal of Clinical Medicine Research >Metabolic Functions of the Lung, Disorders and Associated Pathologies
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Metabolic Functions of the Lung, Disorders and Associated Pathologies

机译：肺的代谢功能，疾病和相关病理

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The primary function of the lungs is gas exchange. Approximately 400 million years ago, the Earth’s atmosphere gained enough oxygen in the gas phase for the animals that emerged from the sea to breathe air. The first lungs were merely primitive air sacs with a few vessels in the walls that served as accessory organs of gas exchange to supplement the gills. Eons later, as animals grew accustomed to a solely terrestrial life, the lungs became highly compartmentalized to provide the vast air-blood surface necessary for O2 uptake and CO2 elimination, and a respiratory control system was developed to regulate breathing in accordance with metabolic demands and other needs. With the evolution and phylogenetic development, lungs were taking a variety of other specialized functions to maintain homeostasis, which we will call the non-respiratory functions of the lung and that often, and by mistake, are believed to have little or no connection with the replacement gas. In this review, we focus on the metabolic functions of the lung, perhaps the least known, and mainly, in the lipid metabolism and blood-adult lung vascular endothelium interaction. When these functions are altered, respiratory disorders or diseases appear, which are discussed concisely, emphasizing how they impact the most important function of the lungs: external respiration.J Clin Med Res. 2016;8(10):689-700doi: http://dx.doi.org/10.14740/jocmr2668w
机译：肺的主要功能是气体交换。大约4亿年前，地球大气层在气相中获得了足够的氧气，以使从海中出来的动物能够呼吸空气。最初的肺仅是原始的气囊，壁上有一些血管，可作为气体交换的辅助器官以补充supplement。不久之后，随着动物逐渐习惯于陆地生活，肺部高度分隔开来，为摄取O2和消除CO2提供了广阔的气血表面，并开发了呼吸控制系统来根据新陈代谢的需要调节呼吸。其他需求。随着进化和系统发育的发展，肺部正在采取其他各种专门功能来维持体内平衡，我们将其称为肺部的非呼吸功能，并且通常并被错误地认为与肺部几乎没有关联。替代气体。在这篇综述中，我们集中于肺的代谢功能，也许是鲜为人知的，主要是在脂质代谢和血液-成人肺血管内皮相互作用中。当这些功能发生变化时，就会出现呼吸系统疾病或疾病，将对此进行简要讨论，并着重强调它们如何影响肺部最重要的功能：外部呼吸。 2016; 8（10）：689-700doi：http://dx.doi.org/10.14740/jocmr2668w

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