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首页> 外文期刊>Journal of Clinical Medicine Research >Comorbidity and inflammatory markers may contribute to predict mortality of high-risk patients with COPD exacerbation
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Comorbidity and inflammatory markers may contribute to predict mortality of high-risk patients with COPD exacerbation

机译：合并症和炎性标志物可能有助于预测COPD恶化的高危患者的死亡率

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Background: Acute exacerbation of chronic obstructive pulmonary disease (COPD) causes not only an accelerated disease progression, but also an increased mortality rate. The purpose of this study was to analyze the factors associated with clinical features, comorbidities and mortality in patients at high risk for acute COPD exacerbation who had been hospitalized at least once in a year.Methods: The study enrolled 606 patients who had been diagnosed with and were being treated for COPD at university affiliated hospital. Among them, there were 61 patients at high risk for acute exacerbation of COPD who had been hospitalized at least once in a year. A retrospective analysis was conducted to examine the factors affecting mortality. The analysis divided the patients into non-survivor and survivor groups, and reviewed their medical records for clinical aspects, comorbidities, pulmonary function tests and blood tests.Results: In the high-risk group, the number of comorbidities at diagnosis (P = 0.020) and the Charlson comorbidity index value (P = 0.018) were higher in the non-survivor group than in the survivor group. During hospitalization, the non-survivor group had a significantly higher neutrophil (%) and a significantly lower lymphocyte (%) in complete blood count. Under stable conditions, the high-sensitivity C-reactive protein (hsCRP) concentration in blood plasma and neutrophil (%) were significantly higher (P = 0.025 and P = 0.036), while the lymphocyte (%) was significantly lower (P = 0.005) in the non-survivor group. A pulmonary function test revealed no statistically significant differences between the two groups.Conclusion: The number of comorbidities, neutrophil (%), lymphocyte (%) in complete blood cell (CBC) and hsCRP in blood plasma concentration among the groups at high risk for COPD exacerbation are associated with increased mortality.J Clin Med Res. 2016;8(7):531-536doi: http://dx.doi.org/10.14740/jocmr2594w
机译：背景：慢性阻塞性肺疾病（COPD）的急性加重不仅导致疾病进展加快，而且导致死亡率增加。这项研究的目的是分析与每年至少住院一次的急性COPD急性发作高风险患者的临床特征，合并症和死亡率相关的因素。方法：该研究纳入了606名被确诊患有COPD的患者并在大学附属医院接受COPD治疗。其中，有61名每年至少住院一次的COPD急性加重高危患者。进行回顾性分析以检查影响死亡率的因素。分析将患者分为非幸存者和幸存者组，并回顾了他们的医学记录，包括临床方面，合并症，肺功能检查和血液检查。结果：在高风险组中，诊断出合并症的数量（P = 0.020） ）和非存活者组的Charlson合并症指数值（P = 0.018）高于存活者组。在住院期间，非幸存者组的全血细胞计数中性粒细胞（％）明显较高，淋巴细胞（％）明显较低。在稳定条件下，血浆和中性粒细胞中的高敏感性C反应蛋白（hsCRP）浓度显着较高（P = 0.025和P = 0.036），而淋巴细胞（％）则显着较低（P = 0.005） ）在非幸存者组中。肺功能测试显示两组之间无统计学差异。结论：高危人群中合并症的数量，全血细胞（CBC）中的中性粒细胞（％），淋巴细胞（％）和血浆中hsCRP的数量COPD恶化与死亡率增加有关。《临床医学杂志》。 2016; 8（7）：531-536doi：http://dx.doi.org/10.14740/jocmr2594w

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