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首页> 外文期刊>Journal of Clinical Medicine Research >Prolonged Rupture of Membranes, Neonatal Outcomes and Management Guidelines
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Prolonged Rupture of Membranes, Neonatal Outcomes and Management Guidelines

机译：长时间的胎膜破裂，新生儿结局和治疗指南

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Background: Prolonged rupture of membranes (PROM) is a risk factor for early-onset neonatal sepsis (EOS). In the absence of early specific and sensitive diagnostic tools, management of asymptomatic infants is difficult. This study was conducted to investigate clinical outcomes of newborns born to mothers with PROM. Methods: A retrospective study of neonates ≥ 34 weeks admitted due to PROM was conducted. Medical charts were reviewed. Neonates were classified into three categories based on their status at birth: ill appearing, well, and equivocal. Sepsis risk calculator was retrospectively applied. Results: A total of 176 neonates were included. All mothers had unknown group B streptococcus (GBS) status. Of them, 74.4% were asymptomatic. Nine infants (5%) had positive cultures, and 23 infants (13%) had culture-negative sepsis. The newborns with sepsis fit into the “ill appearing” category with a significantly higher proportion (12.5% vs. 0.0%, P value 0.0). Conclusions: Reliable early diagnostic tools for neonatal sepsis are lacking. Adopting a protocol that utilizes multiple methods and follow-up for the clinical condition of these infants are the key factors to avoid missing neonates with true sepsis and decreasing the use of antibiotics in those without infection.
机译：背景：长时间的胎膜破裂（PROM）是早发性新生儿败血症（EOS）的危险因素。在缺乏早期特异性和敏感性诊断工具的情况下，无症状婴儿的治疗非常困难。这项研究的目的是调查患有PROM的母亲所生新生儿的临床结局。方法：回顾性研究了因PROM而入院的≥34周的新生儿。检查了病历。新生儿根据出生时的状态分为三类：不适，健康和模棱两可。追溯应用败血症风险计算器。结果：共纳入176例新生儿。所有母亲的B组链球菌（GBS）状况均未知。其中，74.4％无症状。 9名婴儿（5％）的文化为阳性，23名婴儿（13％）的文化为败血症。败血症新生儿的比例明显更高（12.5％vs. 0.0％，P值<0.0），属于“出现不良”类别。结论：缺乏可靠的新生儿败血症诊断工具。对于这些婴儿的临床状况，采用能够采用多种方法进行随访的方案是避免患有真正败血症的新生儿丢失并减少无感染者抗生素使用的关键因素。

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