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首页> 外文期刊>Journal of Clinical Medicine >Pathogenic Role of IL-17-Producing Immune Cells in Obesity, and Related Inflammatory Diseases
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Pathogenic Role of IL-17-Producing Immune Cells in Obesity, and Related Inflammatory Diseases

机译：产生IL-17的免疫细胞在肥胖症和相关炎性疾病中的致病作用

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摘要

Obesity is associated with low-grade chronic inflammation. Indeed, adipose tissues (AT) in obese individuals are the former site of progressive infiltration by pro-inflammatory immune cells, which together with increased inflammatory adipokine secretion induce adipocyte insulin resistance. IL-17-producing T (Th17) cells are part of obese AT infiltrating cells, and are likely to be promoted by adipose tissue-derived mesenchymal stem cells, as previously reported by our team. Whereas Th17 cell are physiologically implicated in the neutralization of fungal and bacterial pathogens through activation of neutrophils, they may also play a pivotal role in the onset and/or progression of chronic inflammatory diseases, or cancer, in which obesity is recognized as a risk factor. In this review, we will highlight the pathogenic role of IL-17A producing cells in the mechanisms leading to inflammation in obesity and to progression of obesity-related inflammatory diseases.
机译：肥胖与低度慢性炎症有关。实际上，肥胖个体中的脂肪组织（AT）是促炎性免疫细胞进行性浸润的前一个部位，其与炎性脂肪因子的增加分泌一起诱导了脂肪细胞胰岛素抵抗。产生IL-17的T（Th17）细胞是肥胖AT浸润细胞的一部分，并且可能由脂肪组织衍生的间充质干细胞促进。尽管Th17细胞通过中性粒细胞的活化在生理上与真菌和细菌病原体的中和有关，但它们在慢性炎症性疾病或癌症的发作和/或进展中也可能起关键作用，其中肥胖被认为是危险因素。在这篇综述中，我们将重点介绍产生IL-17A的细胞在导致肥胖症炎症以及与肥胖相关的炎症性疾病进展的机制中的致病作用。

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