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首页> 外文期刊>Journal of Clinical Medicine Research >Epicardial Adipose Tissue Thickness and Its Association With the Presence and Severity of Coronary Artery Disease in Clinical Setting: A Cross-Sectional Observational Study
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Epicardial Adipose Tissue Thickness and Its Association With the Presence and Severity of Coronary Artery Disease in Clinical Setting: A Cross-Sectional Observational Study

机译：心外膜脂肪组织厚度及其与临床环境中冠状动脉疾病的严重程度的关系：一项跨部门的观察性研究

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Background: Obesity is an important risk factor for atherosclerotic cardiovascular disease (ASCVD). Estimation of visceral adipose tissue is important and several methods are available as its surrogate. Although correlation of epicardial adipose tissue (EAT) with visceral adipose tissue as estimated by magnetic resonance imaging (MRI) and/or CT is excellent, it is costlier and cumbersome. EAT can be accurately measured by two-dimensional (2D) echocardiography. It tends to be higher in patients with acute coronary syndrome than in subjects without coronary artery disease (CAD) and in those with stable angina. It also carries advantage as index of high cardiometabolic risk as it is a direct measure of visceral fat rather than anthropometric measurements. The present study evaluated the relationship of EAT to the presence and severity of CAD in clinical setting.Methods: In this prospective, single-center study conducted in the Department of Cardiology, LPS Institute of Cardiology, Kanpur, India, 549 consecutive patients with acute coronary syndrome or chronic stable angina were enrolled. Sensitivity, specificity, and receiver operating characteristic (ROC) curve were estimated to find cut-off value of EAT thickness for diagnosing CAD using coronary angiographic findings as gold standard.Results: Patients were diagnosed as CAD group (n = 464, 60.30 ± 8.36 years) and non-CAD group (n = 85, 54.42 ± 11.93 years) after assessing coronary angiograms. The EAT was measured at end-systole from the PLAX views of three cardiac cycles on the free wall of the right ventricle. Lesion was significant if > 50% in left main and > 70% in other coronary arteries. The mean EAT thickness in CAD group was 5.10 ± 1.06 and in non-CAD group was 4.36 ± 1.01 which was significant (P = 0.003). Significant correlation was demonstrated between EAT thickness and presence of CAD (P 4.65 mm predicated the presence of significant coronary stenosis by 71.6% sensitivity and 73.1% specificity.Conclusion: EAT thickness measured using transthoracic echocardiography (TTE) significantly correlates with the presence and severity of CAD. It is sensitive, easily available, and cost-effective and assists in the risk stratification and may be an additional marker on classical risk factors for CAD.J Clin Med Res. 2016;8(5):410-419doi: http://dx.doi.org/10.14740/jocmr2468w
机译：背景：肥胖是动脉粥样硬化性心血管疾病（ASCVD）的重要危险因素。内脏脂肪组织的估计很重要，有几种方法可以替代它。尽管通过磁共振成像（MRI）和/或CT估计心外膜脂肪组织（EAT）与内脏脂肪组织之间的相关性极好，但是它既昂贵又麻烦。 EAT可以通过二维（2D）超声心动图进行准确测量。与没有冠心病（CAD）的患者和患有稳定型心绞痛的患者相比，急性冠脉综合征的患者倾向于更高。它也可以作为心脏代谢风险高的指标，因为它是内脏脂肪的直接量度而不是人体测量法。本研究评估了EAT与临床环境中CAD的存在和严重性之间的关系。方法：在这项前瞻性，单中心研究中，印度坎普尔LPS心脏病研究所LPS心脏病学系进行的549例急性患者纳入冠状动脉综合征或慢性稳定型心绞痛。以冠状动脉造影结果为金标准，估计敏感性，特异性和受体工作特征（ROC）曲线以求出EAT厚度的临界值，以诊断CAD。结果：患者被诊断为CAD组（n = 464，60.30±8.36年）和非CAD组（n = 85，54.42±11.93年），评估冠状动脉造影后。从右心室自由壁上三个心动周期的PLAX观点测量收缩期末的EAT。如果左主干> 50％，其他冠状动脉> 70％，则病变明显。 CAD组的平均EAT厚度为5.10±1.06，非CAD组的平均EAT厚度为4.36±1.01，这是显着的（P = 0.003）。 EAT厚度与CAD的存在之间存在显着相关性（P 4.65 mm通过显着性71.6％的敏感性和73.1％的特异性预测显着的冠状动脉狭窄的存在。 CAD。它灵敏，容易获得且具有成本效益，并且有助于风险分层，并且可能是CAD的经典风险因素的另外一种标记。JClin Med Res。2016; 8（5）：410-419doi：http： //dx.doi.org/10.14740/jocmr2468w

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