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首页> 外文期刊>Journal of Clinical Medicine Research >Microalbuminuria: Correlation With Prevalence and Severity of Coronary Artery Disease in Non-Diabetics
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Microalbuminuria: Correlation With Prevalence and Severity of Coronary Artery Disease in Non-Diabetics

机译：微量白蛋白尿：与非糖尿病患者冠状动脉疾病的患病率和严重程度相关

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Background: Previous studies have shown that microalbuminuria (MAU) is an independent risk factor for cardiovascular diseases in diabetics, hypertensive patients and in the general population. However, the correlation of MAU with the severity of coronary artery disease (CAD) in non-diabetic patients has not been addressed in detail. This study aimed to investigate the relationship between MAU and severity of angiographically confirmed CAD in non-diabetic patients.Methods: This was a cross-sectional study, which included 90 non-diabetic patients with documented CAD by coronary angiography. The ratio of urine albumin to creatinine was used to define MAU and severity of CAD was estimated using SYNTAX score. Patients were divided into two groups: group I that included patients without MAU and group II that included patients with MAU.Results: Out of 90 non-diabetic CAD patients, 62 (68.9%) were in group I (MAU negative) and 28 (31.1%) were in group II (MAU positive). There was statistically significant difference in the median SYNTAX score between the groups (21 vs. 28, P < 0.001). The prevalences of double vessel CAD and triple vessel CAD were significantly higher in MAU positive group. There was a strong relationship between the presence of MAU and the extent and complexity of CAD (r = 0.094; P < 0.001).Conclusion: Thus, we conclude that patients with MAU have more severe angiographically detected CAD than those without MAU, and MAU exhibits a significant association with the presence and severity of CAD.J Clin Med Res. 2017;9(10):838-843doi: https://doi.org/10.14740/jocmr2785w
机译：背景：先前的研究表明，微量白蛋白尿（MAU）是糖尿病，高血压患者和普通人群中心血管疾病的独立危险因素。但是，尚未详细探讨非糖尿病患者中MAU与冠状动脉疾病（CAD）严重程度的相关性。这项研究旨在探讨非糖尿病患者的MAU与血管造影确诊的CAD严重程度之间的关系。方法：这是一项横断面研究，其中包括90例通过冠状动脉造影记录了CAD的非糖尿病患者。尿白蛋白与肌酐的比率用于定义MAU，CAD的严重程度通过SYNTAX评分进行估算。患者分为两组：第一组包括无MAU的患者，第二组包括MAU的患者。结果：90例非糖尿病CAD患者中，第一组（MAU阴性）中有62名（68.9％），第二组是（MAU阴性）。 II组（MAU阳性）占31.1％。两组之间的中位数SYNTAX得分有统计学差异（21比28，P <0.001）。在MAU阳性组中，双血管CAD和三血管CAD的患病率明显更高。 MAU的存在与CAD的程度和复杂性之间存在很强的关系（r = 0.094; P <0.001）。结论：因此，我们得出结论：与没有MAU和MAU的患者相比，MAU的患者在血管造影上发现的CAD更为严重与CAD的存在和严重程度密切相关.J Clin Med Res。 2017; 9（10）：838-843doi：https://doi.org/10.14740/jocmr2785w

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