...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical Medicine Research >Serum 25-hydroxyvitamin D and Ethnic Differences in Arterial Stiffness and Endothelial Function
【24h】

Serum 25-hydroxyvitamin D and Ethnic Differences in Arterial Stiffness and Endothelial Function

机译：血清25-羟维生素D与动脉僵硬度和内皮功能的种族差异

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Vitamin D reportedly influences vascular function, which is worse in African Americans (AAs) relative to European Americans (EAs). It is not clear if ethnic differences in 25(OH)D mediate differences in vascular function. This study examined the relationships of serum 25-hydroxyvitamin D (25(OH)D) with indicators of vascular function among healthy, young AA and EA adults. Methods: This is a cross sectional study involving 23 AAs and 22 EAs. The main outcomes were augmentation index (AIx75), central aortic pressure, pulse wave velocity (PWV), flow-mediated dilation (FMD), and seated and supine blood pressures.?Results: Results indicated that 25(OH)D was inversely associated with AIx75, supine systolic blood pressure (SBP), central aortic SBP and central aortic diastolic blood pressure (DBP), independent of age, sex, and percent body fat (standardized b= -0.29 to -0.43, P < 0.05 for all). AAs had greater AIx75 (P = 0.04) and PWV (P = 0.07) and lower FMD (P = 0.02) compared to EA after adjusting for age and percent body fat; further adjustment for 25(OH)D reduced the ethnic differences (P = 0.44, 0.53, and 0.20, respectively). Conclusion: The 25(OH)D was associated with vascular function in healthy adults, and lower 25(OH)D among AAs may contribute to their greater arterial stiffness and reduced endothelial function (Clinical trials.gov NCT01041365, NCT01041547).doi:10.4021/jocmr965w
机译：背景：据报道维生素D影响血管功能，在非洲裔美国人（AAs）中，维生素D相对于欧美人（EAs）更差。尚不清楚25（OH）D的种族差异是否介导了血管功能的差异。这项研究检查了健康，年轻AA和EA成人中血清25-羟基维生素D（25（OH）D）与血管功能指标的关系。方法：这是一项涉及23个AA和22个EA的横断面研究。主要结局为：增强指数（AIx75），主动脉中央压力，脉搏波速度（PWV），血流介导的扩张（FMD），坐位和仰卧位血压。结果：结果表明25（OH）D呈负相关具有AIx75，仰卧收缩压（SBP），主动脉中央SBP和中央主动脉舒张压（DBP），与年龄，性别和体脂百分比无关（标准b = -0.29至-0.43，所有P均<0.05） 。在调整了年龄和体脂百分比之后，与EA相比，AA具有更高的AIx75（P = 0.04）和PWV（P = 0.07）和较低的FMD（P = 0.02）;进一步调整25（OH）D可减少种族差异（分别为P = 0.44、0.53和0.20）。结论：健康成年人的25（OH）D与血管功能有关，而AA中较低的25（OH）D可能有助于其更大的动脉僵硬度和降低的内皮功能（临床试验。govNCT01041365，NCT01041547）.doi：10.4021 / jocmr965w

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号