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首页> 外文期刊>Journal of Clinical Medicine Research >Secular Trends in the Clinical Characteristics of Type 2 Diabetic Patients With Severe Hypoglycemia Between 2008 and 2013
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Secular Trends in the Clinical Characteristics of Type 2 Diabetic Patients With Severe Hypoglycemia Between 2008 and 2013

机译：2008年至2013年间2型糖尿病伴重度低血糖患者的临床特征的长期趋势

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Background: We investigated the trends in the clinical characteristics and prescriptions of type 2 diabetic patients with severe hypoglycemia because the prescription rate of antidiabetic agents has significantly changed recently.Methods: A total of 193 patients with type 2 diabetes with severe hypoglycemia induced by antidiabetic agents between 2008 and 2013 were divided into three groups based on the period of visit: 2008 - 2009, 2010 - 2011 and 2012 - 2013.Results: While the proportion of patients with severe hypoglycemia using insulin (from 55% to 74%), biguanides (from 6% to 20%), glinides, and dipeptidyl peptidase-4 inhibitors significantly increased, those using sulfonylureas (from 45% to 20%) significantly decreased. Errors of drug use significantly increased as a trigger of hypoglycemia in recent years. The number of antidiabetic agents (from 1.9 ± 0.6 to 2.3 ± 0.7), non-diabetic agents (from 2.3 ± 2.4 to 4.3 ± 3.3), and total drugs prescribed were significantly higher in recent years among patients receiving insulin therapy.Conclusions: Polypharmacy especially in patients receiving insulin therapy and errors of drug use have increased in type 2 diabetic patients with severe hypoglycemia in recent years. Intensive education in the usage rule of drugs is considered to be important in order to prevent severe hypoglycemia.J Clin Med Res. 2016;8(10):710-714doi: http://dx.doi.org/10.14740/jocmr2610w
机译：背景：由于近来抗糖尿病药的处方率发生了显着变化，我们调查了2型糖尿病重症低血糖患者的临床特征和处方趋势。方法：总共193例2型糖尿病由重症降糖药诱发的患者根据就诊时间将2008年至2013年之间的患者分为三组：2008年至2009年，2010年至2011年和2012年至2013年。结果：虽然严重低血糖患者使用胰岛素的比例（从55％到74％），但双胍类药物（从6％到20％），格列奈酯和二肽基肽酶-4抑制剂显着增加，而使用磺脲类药物的抑制剂（从45％到20％）显着减少。近年来，由于低血糖的触发，吸毒错误显着增加。近年来，接受胰岛素治疗的患者中抗糖尿病药的数量（从1.9±0.6到2.3±0.7），非糖尿病药物（从2.3±2.4到4.3±3.3）和处方药总数显着增加。特别是在接受胰岛素治疗的患者中，近年来严重低血糖的2型糖尿病患者的用药错误增加了。为了防止严重的低血糖症，对药物的使用规则进行严格的教育被认为是重要的。 2016; 8（10）：710-714doi：http://dx.doi.org/10.14740/jocmr2610w

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