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首页> 外文期刊>Journal of Clinical Medicine Research >Pharmacokinetic Changes and Dosing Modification of Aminoglycosides in Critically Ill Obese Patients: A Literature Review
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Pharmacokinetic Changes and Dosing Modification of Aminoglycosides in Critically Ill Obese Patients: A Literature Review

机译：重症肥胖患者氨基糖苷的药代动力学变化和剂量修饰：文献综述

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The objective of the paper is to review the literature and provide recommendations for use of aminoglycoside antibiotics in critically ill obese patients. Literature search in PubMed for all articles on the use of aminoglycosides in critically ill obese patients was conducted, and all articles related to pharmacokinetics in obesity were reviewed. Bibliographies of all searched manuscripts were also reviewed in an attempt to find additional references. Although aminoglycoside pharmacokinetics have been described in detail, data on aminoglycoside use and appropriate dose modification in critically ill obese patients are very limited. Knowledge on aminoglycoside pharmacokinetics and use in critically ill obese patients is incomplete. Pathophysiologic changes in obesity can result in sub- or supra-therapeutic aminoglycoside plasma concentrations, especially in the presence of sepsis. Rigorous clinical studies are needed to establish aminoglycoside dosing guidelines in critically ill obese patients with sepsis.J Clin Med Res. 2014;6(4):227-233doi: http://dx.doi.org/10.14740/jocmr1858w
机译：本文的目的是回顾文献并为重症肥胖患者使用氨基糖苷类抗生素提供建议。在PubMed中检索了有关在危重肥胖患者中使用氨基糖苷类药物的所有文章，并复习了与肥胖症中药代动力学相关的所有文章。还对所有检索到的手稿的书目进行了审查，以寻找其他参考文献。尽管已经详细描述了氨基糖苷的药代动力学，但是在危重肥胖患者中使用氨基糖苷和适当调整剂量的数据非常有限。对重症肥胖患者的氨基糖苷药代动力学及其使用的知识尚不完善。肥胖的病理生理变化可能导致亚糖苷或亚糖苷治疗浓度升高，特别是在存在败血症的情况下。建立重症肥胖脓毒症患者的氨基糖苷剂量指南需要严格的临床研究。 2014; 6（4）：227-233doi：http://dx.doi.org/10.14740/jocmr1858w

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