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首页> 外文期刊>Journal of Clinical Medicine Research >Vertebral Osteomyelitis: An Under-Recognized Infectious Complication in Patients on Home Parenteral Nutrition
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Vertebral Osteomyelitis: An Under-Recognized Infectious Complication in Patients on Home Parenteral Nutrition

机译：椎体骨髓炎：家庭肠外营养患者的一种公认的感染并发症。

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Background: Patients on home parenteral nutrition (HPN) are at high risk of central venous catheter sepsis (CVCS). CVCS can be associated with distant bacterial seeding. However, few cases of vertebral osteomyelitis (VO) related to HPN have been reported. For this reason, we made the hypothesis that the incidence of VO in patients on HPN is probably higher than what is reported. The goal of this study was to evaluate the incidence of infectious complications, and more specifically, the incidence of VO in patients on HPN. Methods: A retrospective study of all patients receiving HPN from 2001 to 2006 was conducted. Patients who received HPN for < 1 month were excluded. Infectious complications and, more specifically, cases of VO were searched. Results: Thirty-one patients received HPN and were included in the analysis. Forty-four infectious complications occurred (1.302/1,000 CVC-days). The most frequent infectious complication was urinary tract infection (25 cases; 0.740/1,000 CVC-days). Seven CVCS occurred in five different patients (0.207/1,000 CVC-days). In patients with CVCS, 42.9% (three cases) developed a secondary VO. No predictive factors for the development of VO could be identified in univariate analysis. Conclusion: We report a very low rate of infectious complications and an even lower rate of CVCS in patients on HPN. However, we report that 42.9% of our cases of CVCS developed a secondary VO. Consequently, VO must be part of the differential diagnosis among patients with HPN who complain of back pain.J Clin Med Res. 2014;6(4):272-277 doi: http://dx.doi.org/10.14740/jocmr1825w
机译：背景：接受家庭肠外营养（HPN）的患者发生中心静脉导管脓毒症（CVCS）的风险很高。 CVCS可能与遥远的细菌播种有关。但是，鲜有与HPN相关的椎骨骨髓炎（VO）病例报道。由于这个原因，我们提出了一个假设，即HPN患者中VO的发生率可能高于所报道的水平。这项研究的目的是评估感染并发症的发生率，更具体地说，是评估HPN患者中VO的发生率。方法：对2001年至2006年接受HPN治疗的所有患者进行回顾性研究。排除接受HPN <1个月的患者。搜索感染并发症，更具体地说是VO病例。结果：31例患者接受了HPN并被纳入分析。发生四十四次感染并发症（1.302 / 1,000 CVC天）。最常见的感染并发症是尿路感染（25例; 0.740 / 1,000 CVC天）。在五名不同的患者中发生了七次CVCS（0.207 / 1,000 CVC天）。在CVCS患者中，有42.9％（三例）发展为继发性VO。在单变量分析中不能确定VO发生的预测因素。结论：我们报告HPN患者的感染并发症发生率非常低，CVCS发生率甚至更低。但是，我们报告说，在我们的CVCS案例中，有42.9％发生了二次VO。因此，在抱怨背部疼痛的HPN患者中，VO必须成为鉴别诊断的一部分。JClin Med Res。 2014; 6（4）：272-277 doi：http://dx.doi.org/10.14740/jocmr1825w

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