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首页> 外文期刊>Journal of Clinical Medicine Research >Prevalence of Elevated Glycated Hemoglobin Concentrations in the Polycystic Ovary Syndrome: Anthropometrical and Metabolic Relationship in Amazonian Women
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Prevalence of Elevated Glycated Hemoglobin Concentrations in the Polycystic Ovary Syndrome: Anthropometrical and Metabolic Relationship in Amazonian Women

机译：多囊卵巢综合征中糖化血红蛋白浓度升高的流行：亚马逊妇女的人体测量和代谢关系。

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Background: To determine the prevalence of elevated glycated hemoglobin (HbA1c) and to examine its relationship with other carbohydrate metabolic parameter among Brazilian women with polycystic ovary syndrome (PCOS). Methods: A cross-sectional study including 288 PCOS patients was conducted. Anthropometrical, clinical, biochemical and endocrine parameters were evaluated. Results: The mean age was 26.92 ± 5.51 years. HbA1c mean concentration was 5.83±1.34%. In 38.54% of patients, HbA1c was ≥ 5.7%. HbA1c was positively correlated with body weight (r = 0.142, P = 0.017), body mass index (P = 0.000), waist:hip ratio (P = 0.000), fat mass (P = 0.000), conicity index (P = 0.000), triglyceride (P = 0.001), C-peptide (P = 0.000), total testosterone (P = 0.003), free testosterone (P = 0.000), free androgen index (P = 0.006) and fasting insulin (P = 0.025). Using the oral glucose tolerance test, HbA1c showed positive correlation with glucose concentrations at any point in time (P < 0.05). Conclusions: HbA1c was elevated in nearly 40% of PCOS patients and it showed positive correlation with several anthropometric and metabolic factors and androgen levels. The current study provides further evidence that HbA1C is higher in PCOS patients and may have a potential role in the prediction of dysglycemic disease in these women.J Clin Med Res. 2014;6(4):278-286doi: http://dx.doi.org/10.14740/jocmr1829w
机译：背景：确定糖化血红蛋白（HbA1c）升高的患病率，并检查其与巴西多囊卵巢综合征（PCOS）妇女其他碳水化合物代谢参数的关系。方法：进行了一项包括288名PCOS患者的横断面研究。评估人体测量学，临床，生化和内分泌参数。结果：平均年龄为26.92±5.51岁。 HbA1c平均浓度为5.83±1.34％。在38.54％的患者中，HbA1c≥5.7％。 HbA1c与体重（r = 0.142，P = 0.017），体重指数（P = 0.000），腰围：臀围比率（P = 0.000），脂肪量（P = 0.000），锥度指数（P = 0.000）正相关。 ），甘油三酸酯（P = 0.001），C肽（P = 0.000），总睾丸激素（P = 0.003），游离睾丸激素（P = 0.000），游离雄激素指数（P = 0.006）和空腹胰岛素（P = 0.025） 。使用口服葡萄糖耐量试验，HbA1c在任何时间点均与葡萄糖浓度呈正相关（P <0.05）。结论：HbA1c在近40％的PCOS患者中升高，并且与多种人体测量和代谢因素以及雄激素水平呈正相关。当前的研究提供了进一步的证据，表明PCOS患者中的HbA1C较高，并且可能在这些女性的血糖异常预测中具有潜在作用。 2014; 6（4）：278-286doi：http://dx.doi.org/10.14740/jocmr1829w

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