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首页> 外文期刊>Journal of Clinical Medicine Research >fMRI Under Sedation: What Is the Best Choice in Children?
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fMRI Under Sedation: What Is the Best Choice in Children?

机译：镇静下的功能磁共振成像：儿童的最佳选择是什么？

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Background: Pediatric fMRI may require sedation. The aim of this study is to compare different sedation schemes to determine which medication yields least failures and the best activation. Methods: A total of 100 children who had fMRI performed as part of the work up for epilepsy surgery, were divided into different medication groups (Pentobarbital, Propofol, Dexmedetomidine, Sevoflurane). Comparison was performed among the groups for number of failures, rank of activation, adverse effects, anesthesia time, and recovery time. The study was approved by the IRB and followed all HIPAA guidelines. BOLD sequences were utilized to perform two block-design paradigms (auditory and visual). The activation was ranked into 5 categories according to the presence and localization of the activation. Descriptive and parametric statistics (ANOVA) were utilized to look for significant differences. Results: Pentobarbital yielded the least amount of failures, for the auditory task, followed by propofol, while sevoflurane yielded the highest number of failures for both tasks. In the visual task, propofol administered after dexmedetomidine resulted in the least number of failures. Brain activations were not statistical different (auditory: ANOVA, P = 0.42; F = 1.01; visual: ANOVA, P = 0.077; F = 2.1). The shortest recovery time was obtained with sevoflurane, followed by propofol. Agitation and cardiac complications were seen in 28% of cases in the pentobarbital group. Conclusion: No statistically significant difference in brain activation was found utilizing different sedative medications in children with intractable epilepsy. A trend toward less failures was obtained with pentobarbital and propofol; however pentobarbital was more frequently associated with undesirable side effects. doi: http://dx.doi.org/10.4021/jocmr1047w
机译：背景：小儿功能磁共振成像可能需要镇静剂。这项研究的目的是比较不同的镇静方案，以确定哪种药物产生最少的失败和最好的激活。方法：将作为癫痫手术后一部分进行功能磁共振成像的100名儿童分为不同的药物治疗组（戊巴比妥，丙泊酚，右美托咪定，七氟醚）。比较各组之间的失败次数，激活程度，不良反应，麻醉时间和恢复时间。该研究已获得IRB的批准，并遵循了所有HIPAA指南。 BOLD序列用于执行两个块设计范例（听觉和视觉）。根据激活的存在和位置，将激活分为5类。描述性和参数统计（ANOVA）用于寻找显着差异。结果：对于听觉任务，戊巴比妥产生的失败次数最少，其次是异丙酚，而七氟醚在两项任务产生的失败次数最多。在视觉任务中，右美托咪定后给予丙泊酚的失败次数最少。脑部激活没有统计学差异（听觉：ANOVA，P = 0.42; F = 1.01;视觉：ANOVA，P = 0.077; F = 2.1）。七氟醚和丙泊酚之后的回收时间最短。戊巴比妥组28％的病例出现躁动和心脏并发症。结论：对于顽固性癫痫患儿，使用不同的镇静药物治疗后脑部激活无统计学差异。戊巴比妥和丙泊酚的失败率呈下降趋势。但是戊巴比妥更经常与不良副作用相关。 doi：http：//dx.doi.org/10.4021/jocmr1047w

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